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Find clinical trials for Acute Myeloid Leukemia (AML) in Philadelphia, PA

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Leukemia
Acute Myeloid Leukemia
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Myelodysplastic Syndromes
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Acute Myeloid Leukemia (AML) trials near Philadelphia, PA, USA:

A Study of ASP2215 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase (FLT3) Mutation

The purpose of this study is to determine the clinical benefit of ASP2215 therapy in participants with FMS-like tyrosine kinase (FLT3) mutated acute...

Active, not recruiting
Leukemia, Acute Myeloid (AML)
Drug: MEC (Mitoxantrone, Etoposide, Cytarabine)
Drug: gilteritinib

Phase 3

Astellas
Astellas

Philadelphia, Pennsylvania, United States and 125 other locations

The main objective of this study is to evaluate the efficacy of venetoclax in combination with azacitidine to improve Overall Survival (OS) in Acute...

Active, not recruiting
Acute Myeloid Leukemia (AML)
Cancer
Other: Best Supportive Care (BSC)
Drug: Venetoclax

Phase 3

AbbVie
AbbVie

Philadelphia, Pennsylvania, United States and 164 other locations

Acute myeloid leukemia (AML) is the second most common type of leukemia diagnosed in adults and children ...

Enrolling
Acute Myeloid Leukemia
Drug: ABBV-787

Phase 1

AbbVie
AbbVie

Philadelphia, Pennsylvania, United States and 20 other locations

The purpose of the phase 1 portion (dose escalation) of the study will be to establish an optimally safe and biologically active recommended phase 2...

Enrolling
Acute Myeloid Leukemia With FMS-like Tyrosine Kinase 3 (FLT3) Mutation / Internal Tandem Duplication (ITD)
Acute Myeloid Leukemia (AML)
Drug: fludarabine
Drug: granulocyte colony-stimulating factor (G-CSF)

Phase 1, Phase 2

Astellas
Astellas

Philadelphia, Pennsylvania, United States and 24 other locations

People with acute myeloid leukemia (AML) are usually treated with chemotherapy. Some people with AML hav...

Enrolling
Acute Myeloid Leukemia (AML)
FLT3-mutated Acute Myeloid Leukemia
Drug: Venetoclax
Drug: Gilteritinib

Phase 1, Phase 2

Astellas
Astellas

Philadelphia, Pennsylvania, United States and 18 other locations

or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it has come back after remission or i...

Enrolling
Acute Myeloid Leukemia
Drug: Quizartinib
Drug: Etoposide

Phase 1, Phase 2

Daiichi Sankyo
Daiichi Sankyo

Philadelphia, Pennsylvania, United States and 36 other locations

\[GO\]) improves survival of children/adolescents/young adults with acute myeloid leukemia (AML) in 1st relapse w...

Enrolling
Acute Myeloid Leukemia
Drug: Venetoclax
Drug: Fludarabine

Phase 3

LLS PedAL Initiative, LLC

Philadelphia, Pennsylvania, United States and 73 other locations

Recently updated

This study will be conducted in two parts. Part 1 will be the Dose Confirmation portion to determine recommended Phase 3 dose (RPTD) of venetoclax in...

Active, not recruiting
Acute Myeloid Leukemia (AML)
Drug: Venetoclax
Drug: Azacitidine

Phase 3

AbbVie
AbbVie

Philadelphia, Pennsylvania, United States of America and 159 other locations

combination with all-trans retinoic acid (ATRA) in participants with acute myeloid leukemia (AML) who have relaps...

Active, not recruiting
Acute Myeloid Leukemia
Drug: TAS1440
Drug: TAS1440 + ATRA

Phase 1

Taiho Pharma
Taiho Pharma

Philadelphia, Pennsylvania, United States and 7 other locations

Eligible untreated patients with FLT3 acute myeloid leukemia (AML) between the ages of 18 and 70 will be randomiz...

Active, not recruiting
Acute Myeloid Leukemia
Drug: Gilteritinib
Drug: Daunorubicin

Phase 2

PrECOG

Philadelphia, Pennsylvania, United States and 43 other locations

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