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Find clinical trials for Adenocarcinoma in Indianapolis, IN

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Carcinoma
Cancer
Pancreatic Cancer
Colorectal Cancer
Stomach Cancer
Prostatic Cancer
Esophageal Cancer

Adenocarcinoma trials near Indianapolis, IN, USA:

A Study of the Safety and Activity of Liposomal Irinotecan in Combination With the 5-FU and Oxaliplatin in the Preoperative Treatment of Pancreatic Adenocarcinoma

resectable or borderline resectable, previously untreated pancreatic adenocarcinoma. The primary objective of this study is to investigate t...

Active, not recruiting
Pancreatic Adenocarcinoma
Drug: Liposomal Irinotecan
Drug: FOLFOX regimen

Phase 2

University of Florida
University of Florida

Indianapolis, Indiana, United States and 3 other locations

and capecitabine monotherapy in patients with metastatic pancreatic adenocarcinoma whose disease has not progressed on a first line fluoropy...

Enrolling
Metastatic Pancreatic Adenocarcinoma
Drug: Capecitabine
Drug: Ivaltinostat

Phase 1, Phase 2

CG Pharmaceuticals

Indianapolis, Indiana, United States and 16 other locations

Patients can be prescreened for the study at the time of diagnosis of locally advanced or metastatic disease by determining presence of LOH high stat...

Active, not recruiting
Adenocarcinoma
Gastric Cancer
Drug: Niraparib

Phase 2

Shadia Jalal, MD

Indianapolis, Indiana, United States and 3 other locations

The purpose of this study is to determine the Objective Response Rate (ORR) of zolbetuzimab as a single agent as assessed by an independent central r...

Enrolling
Pharmacokinetics of Oxaliplatin
Pharmacokinetics of Zolbetuximab
Drug: folinic acid
Drug: fluorouracil

Phase 2

Astellas
Astellas

Indianapolis, Indiana, United States and 25 other locations

Locations recently updated

a dose expansion phase to confirm the dose and combination with bevacizumab. Approximately 500 adult participants with NSCLC, gastroesophageal adenocarcinoma...

Enrolling
Gastroesophageal Adenocarcinoma
Advanced Solid Tumors
Drug: ABBV-400
Drug: Trifluridine/Tipiracil

Phase 1

AbbVie
AbbVie

Indianapolis, Indiana, United States and 79 other locations

This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

Enrolling
High Grade Serous Adenocarcinoma of Ovary
Gastric Adenocarcinoma
Drug: VLS-1488

Phase 1, Phase 2

Volastra Therapeutics

Indianapolis, Indiana, United States and 8 other locations

The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6)...

Enrolling
Gastroesophageal Junction Adenocarcinoma
Gastric Cancer
Drug: Bemarituzumab
Drug: Placebo

Phase 3

Amgen
Amgen

Indianapolis, Indiana, United States and 296 other locations

To investigate the combination of nivolumab and ipilimumab with panitumumab in subjects with unresectable, refractory, KRAS/NRAS/BRAF wild-type, micr...

Active, not recruiting
Colon Cancer
Drug: Nivolumab
Drug: Ipilimumab

Phase 2

UNC Lineberger Comprehensive Cancer Center

Indianapolis, Indiana, United States and 4 other locations

This study looked at how effective the study drug (tepotinib) was at stopping the growth and spread of lung cancer. This study also measures a number...

Active, not recruiting
Lung Adenocarcinoma Stage IIIB/IV
Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET Amplification
Drug: Tepotinib

Phase 2

Merck KGaA (EMD Serono)
Merck KGaA (EMD Serono)

Indianapolis, Indiana, United States and 176 other locations

The primary objectives of this study are to observe the safety and tolerability of bemarituzumab and to evaluate preliminary antitumor activity.

Enrolling
Solid Tumors
Drug: Bemarituzumab

Phase 1, Phase 2

Amgen
Amgen

Indianapolis, Indiana, United States and 109 other locations

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