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and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndr...
Phase 1, Phase 2
Fairway, Kansas, United States and 18 other locations
To investigate safety, tolerability, the effects on cognition and brain metabolism of pepinemab in early AD dementia (early AD) subjects.
Phase 1, Phase 2
Fairway, Kansas, United States and 13 other locations
is superior to placebo on change from baseline of the Preclinical Alzheimer Cognitive Composite 5 (PACC5) at 216 weeks of treatment (A45 Tri...
Phase 3
Fairway, Kansas, United States and 116 other locations
This study will be conducted to evaluate the efficacy of lecanemab in participants with early Alzheimer's disease (EAD) by determin...
Phase 3
Kansas City, Kansas, United States and 246 other locations
of emraclidine administered orally to healthy elderly participants in Part A (multiple ascending doses) and participants with dementia due to Alzheimer's...
Phase 1
Overland Park, Kansas, United States and 10 other locations
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease...
Phase 3
Overland Park, Kansas, United States and 232 other locations
as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's...
Phase 3
Fairway, Kansas, United States and 210 other locations
The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease...
Phase 3
North Kansas City, Missouri, United States and 276 other locations
The primary objective is to evaluate the safety and tolerability of aducanumab over 100 weeks of treatment after a wash-out period imposed by discont...
Phase 3
Fairway, Kansas, United States and 296 other locations
This is an extension study of the Phase 3 Studies 15-AVP-786-301, 15-AVP-786-302, and 17-AVP-786-305, which also allows participants from the Phase 2...
Phase 3
Kansas City, Missouri, United States and 275 other locations
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