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and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndr...
Phase 1, Phase 2
Fairway, Kansas, United States and 16 other locations
To investigate safety, tolerability, the effects on cognition and brain metabolism of pepinemab in early AD dementia (early AD) subjects.
Phase 1, Phase 2
Fairway, Kansas, United States and 13 other locations
is superior to placebo on change from baseline of the Preclinical Alzheimer Cognitive Composite 5 (PACC5) at 216 weeks of treatment (A45 Tri...
Phase 3
Fairway, Kansas, United States and 111 other locations
This study will be conducted to evaluate the efficacy of lecanemab in participants with early Alzheimer's disease (EAD) by determin...
Phase 3
Kansas City, Kansas, United States and 246 other locations
of emraclidine administered orally to healthy elderly participants in Part A (multiple ascending doses) and participants with dementia due to Alzheimer's...
Phase 1
Overland Park, Kansas, United States and 3 other locations
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease...
Phase 3
Overland Park, Kansas, United States and 227 other locations
as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's...
Phase 3
Fairway, Kansas, United States and 210 other locations
The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease...
Phase 3
North Kansas City, Missouri, United States and 275 other locations
The primary objective is to evaluate the safety and tolerability of aducanumab over 100 weeks of treatment after a wash-out period imposed by discont...
Phase 3
Fairway, Kansas, United States and 296 other locations
This is an extension study of the Phase 3 Studies 15-AVP-786-301, 15-AVP-786-302, and 17-AVP-786-305, which also allows participants from the Phase 2...
Phase 3
Kansas City, Missouri, United States and 274 other locations
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