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Find clinical trials for Breast Cancer in Charlotte, NC

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Related conditions:

Triple Negative Breast Cancer
Non-Small-Cell Lung Carcinoma
Neoplasm Metastasis
Cancer
Ovarian Cancer
Colorectal Cancer
Squamous Cell Carcinoma of Head and Neck

Breast Cancer trials near Charlotte, NC, USA:

Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast Cancer (ToPCourT)

in locally advanced unresectable or metastatic triple-negative breast cancer.The main questions it aims to answer are:* to evaluate...

Active, not recruiting
Metastatic Triple-Negative Breast Cancer
Drug: Gemcitabine
Drug: Pembrolizumab

Phase 2

Wake Forest University (WFU)
Wake Forest University (WFU)

Charlotte, North Carolina, United States

postmenopausal patients with HR-positive, HER2-negative metastatic breast cancer. Pre- and perimenopausal women must receive therap...

Active, not recruiting
Breast Cancer
Female Breast Carcinoma
Drug: anastrozole
Drug: Palbociclib

Phase 2

Wake Forest University (WFU)
Wake Forest University (WFU)

Charlotte, North Carolina, United States

in participants with intermediate-risk HR+/HER2- early-stage breast cancer. Based on ctDNA test results, participants will either s...

Enrolling
Carcinoma, Ductal, Breast
Breast Neoplasms
Device: ctDNA-Guided Treatment Strategy
Natera
Natera

Charlotte, North Carolina, United States and 38 other locations

This is a Phase Ib/II, open-label, multicenter, randomized umbrella study in participants with breast cancer. The study is designed...

Enrolling
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
Drug: Inavolisib
Drug: Ipatasertib

Phase 1, Phase 2

Roche
Roche

Charlotte, North Carolina, United States and 31 other locations

the efficacy and safety of palazestrant with ribociclib to letrozole and ribociclib in women and men who have not received prior systemic anti-cancer...

Enrolling
Breast Cancer
ER Positive Breast Cancer
Drug: Palazestrant
Drug: Palazestrant matching-placebo

Phase 3

Olema Pharmaceuticals

Charlotte, North Carolina, United States and 149 other locations

receptor-low/HER2-negative breast cancer....

Active, not recruiting
Breast Cancer
Drug: Epirubicin
Drug: Olaparib

Phase 3

AstraZeneca
AstraZeneca

Charlotte, North Carolina, United States and 282 other locations

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer...

Active, not recruiting
Breast Cancer
Other: Placebo
Drug: Letrozole

Phase 3

National Surgical Adjuvant Breast and Bowel Project Foundation (NSABP)

Charlotte, North Carolina, United States and 805 other locations

This is a Phase 1b open-label, 2-part study in 3 treatment groups. The 3 treatment groups are as follows:Treatment Group 1: Palazestrant (OP-1250) in...

Enrolling
Breast Cancer
ER-positive Breast Cancer
Drug: Atirmociclib
Drug: Palazestrant

Phase 1

Olema Pharmaceuticals

Charlotte, North Carolina, United States and 15 other locations

with previously untreated, locally advanced, unresectable or metastatic (Stage IV) programmed death-ligand 1 (PD-L1)-positive triple-negative breast...

Active, not recruiting
Breast Cancer
Drug: Tobemstomig
Drug: Nab-Paclitaxel

Phase 2

Roche
Roche

Charlotte, North Carolina, United States and 37 other locations

to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence...

Enrolling
Breast Cancer, Early Breast Cancer
Drug: Exemestane
Drug: Anastrozole

Phase 3

AstraZeneca
AstraZeneca

Charlotte, North Carolina, United States and 698 other locations

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