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A phase 1b study to assess the combination of ARV-471 and everolimus in participants with advanced or metastatic ER+/HER2- breast cancer...
Phase 1
Lake Mary, Florida, United States and 8 other locations
Choice (TPC) in advanced metastatic or locally recurrent breast cancer (aMBC) patients with no approved alternative therapies avail...
Phase 3
Orlando, Florida, United States and 47 other locations
breast biopsy occurs if biopsy is needed....
Port Orange, Florida, United States and 3 other locations
The Phase 2 part of the trial will evaluate the efficacy and safety of the various combinations in patients with ER+/HER2- advanced/metastatic breast...
Phase 1, Phase 2
Altamonte Springs, Florida, United States and 115 other locations
endocrine therapy in participants with node-positive, Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor-2 negative (HER2-) early breast...
Phase 3
Altamonte Springs, Florida, United States and 44 other locations
to anti-HER2-based therapy plus endocrine therapy alone in improving the outcomes of subjects with hormone receptor-positive, HER2+ metastatic breast...
Phase 3
Orlando, Florida, United States and 117 other locations
A Global, Phase 2 Study of ARX788 in HER2-positive Metastatic Breast Cancer Patients who were previously treated with T-DXd...
Phase 2
Orlando, Florida, United States and 63 other locations
postmenopausal women with locally advanced or metastatic ER+/HER2- breast cancer with an acquired ESR1 mutation and who have diseas...
Phase 2
Winter Haven, Florida, United States and 50 other locations
This is a first-in-human study of MEN2312, a lysine acetyltransferase 6 (KAT6) inhibitor, in adult participants with advanced breast cancer...
Phase 1
Altamonte Springs, Florida, United States and 19 other locations
positive (HR+) and human epidermal growth factor 2 negative (HER2-) breast cancer (BC) and other advanced solid tumors. Th...
Phase 1
Lake Mary, Florida, United States and 64 other locations
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