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adjuvant systemic treatment instead of adjuvant chemotherapy followed by endocrine therapy in older patients with stage II-III ER+/HER2- early breast...
Phase 2
Sevilla, Spain and 72 other locations
in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-low breast cancer with active brain metastases.This study will ana...
Phase 2
Sevilla, Spain and 12 other locations
-positive / HER2-negative breast cancer which has spread beyond the original tumor and/or to other organs.During this stud...
Phase 3
Sevilla, Spain and 52 other locations
the primary and metastatic (or relapsed) tumor will be collected for central analyses, together with blood, serum and plasma samples. Any s ...
Sevilla, Spain and 51 other locations
DESTINY-Breast07 will investigate the safety, tolerability, and anti-tumour activity of trastuzumab deruxtecan (T-DXd) in combination with o ...
Phase 1, Phase 2
Sevilla, Spain and 71 other locations
participants with metastatic or locally advanced Hormone Receptor (HR) positive and Human Epidermal Growth Factor Receptor (HER)2-negative breast...
Phase 1, Phase 2
Sevilla, Spain and 22 other locations
A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Women with ER Positive, HER2 Negative Advanced Breast Ca...
Phase 1
Sevilla, Spain and 16 other locations
number of mutations per coding area of a tumor genome). The HER2-E and Basal-like profiles have been associated with high mutational burden ...
Phase 2
Sevilla, Spain and 14 other locations
This study to learn more about olaparib and olaparib plus durvalumab combination therapy and also to better understand the studied disease, breast...
Phase 2
Sevilla, Spain and 43 other locations
to anti-HER2-based therapy plus endocrine therapy alone in improving the outcomes of subjects with hormone receptor-positive, HER2+ metastatic breast...
Phase 3
Seville, Spain and 117 other locations
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