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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Cleveland, Ohio, United States and 250 other locations
This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor ...
Phase 1, Phase 2
Cleveland, Ohio, United States and 83 other locations
This study will test the safety of a drug called SGN-EGFRd2 in participants with advanced solid tumors. It will also study the side effects ...
Phase 1
Cleveland, Ohio, United States and 12 other locations
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor...
Phase 2, Phase 3
Cleveland, Ohio, United States and 878 other locations
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody ta...
Phase 1
Cleveland, Ohio, United States and 18 other locations
evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors...
Phase 1, Phase 2
Cleveland, Ohio, United States and 219 other locations
in each subject population expansion cohort of advanced solid tumors that harbor a ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. The seco...
Phase 1, Phase 2
Cleveland, Ohio, United States and 148 other locations
with standard chemotherapy for the potential treatment of colorectal cancer that:* has spread to other parts of the body (metastatic);* has ...
Phase 3
Cleveland, Ohio, United States and 410 other locations
a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon...
Phase 3
Cleveland, Ohio, United States and 989 other locations
The objectives of this study are to evaluate the efficacy and safety of crofelemer treatment in adults affected by Short Bowel Syndrome (SBS) with an...
Early Phase 1
Cleveland, Ohio, United States
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