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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Cleveland, Ohio, United States and 212 other locations
to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer...
Phase 1, Phase 2
Cleveland, Ohio, United States and 83 other locations
the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...
Phase 2, Phase 3
Cleveland, Ohio, United States and 827 other locations
does to the body besides treating the disease.Participants will have cancer that cannot be removed (unresectable) or has spread through the ...
Phase 1
Cleveland, Ohio, United States and 7 other locations
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody ta...
Phase 1
Cleveland, Ohio, United States and 18 other locations
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with adva...
Phase 1, Phase 2
Cleveland, Ohio, United States and 97 other locations
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors an...
Phase 2
Cleveland, Ohio, United States and 79 other locations
with standard chemotherapy for the potential treatment of colorectal cancer that:has spread to other parts of the body (metastatic);has a ce...
Phase 3
Cleveland, Ohio, United States and 409 other locations
a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon...
Phase 3
Cleveland, Ohio, United States and 989 other locations
The objectives of this study are to evaluate the efficacy and safety of crofelemer treatment in adults affected by Short Bowel Syndrome (SBS) with an...
Early Phase 1
Cleveland, Ohio, United States
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