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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Durham, North Carolina, United States and 262 other locations
with histologically or cytologically confirmed stage IV colorectal cancer coming form three different patient populations:* Cohort 1a: 6 pat...
Phase 1
Durham, North Carolina, United States and 11 other locations
This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept effi...
Phase 1
Durham, North Carolina, United States and 10 other locations
to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer...
Phase 1, Phase 2
Chapel Hill, North Carolina, United States and 85 other locations
This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant sol...
Phase 1
Durham, North Carolina, United States and 16 other locations
This first-in-human study will evaluate safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of PHN-012,...
Phase 1
Durham, North Carolina, United States and 25 other locations
The purpose of this study is to assess the safety and tolerability of XmAb®819 administered intravenous (IV) or subcutaneous (SC) in subjects with re...
Phase 1
Durham, North Carolina, United States and 26 other locations
the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...
Phase 2, Phase 3
Durham, North Carolina, United States and 1076 other locations
The main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally ad...
Phase 1
Durham, North Carolina, United States and 46 other locations
chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer....
Phase 3
Chapel Hill, North Carolina, United States and 282 other locations
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