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Find clinical trials for Colon Cancer in Durham, NC

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Related conditions:

Colonic Cancer
Colorectal Cancer
Rectal Cancer
Non-Small-Cell Lung Carcinoma
Pancreatic Cancer
Cancer
Neoplasm Metastasis

Colon Cancer trials near Durham, NC, USA:

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...

Enrolling
Colonic Neoplasms
Neoplasms, Colon
Drug: CAPEOX
Biological: Dostarlimab

Phase 3

GlaxoSmithKline (GSK)
GlaxoSmithKline (GSK)

Durham, North Carolina, United States and 262 other locations

with histologically or cytologically confirmed stage IV colorectal cancer coming form three different patient populations:* Cohort 1a: 6 pat...

Active, not recruiting
Stage IV Rectal Cancer
Metastatic Colorectal Cancer
Drug: ATP128
Drug: BI 754091

Phase 1

Amal Therapeutics

Durham, North Carolina, United States and 11 other locations

This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept effi...

Active, not recruiting
Colon Cancer
Metastatic Colon Cancer
Drug: Fruquintinib
Drug: FOLFIRI regimen & bevacizumab

Phase 1

Sapience Therapeutics

Durham, North Carolina, United States and 10 other locations

to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer...

Active, not recruiting
Colon Cancer
Medullary Thyroid Cancer
Drug: LOXO-292

Phase 1, Phase 2

Lilly
Lilly

Chapel Hill, North Carolina, United States and 85 other locations

This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant sol...

Enrolling
Non-small Cell Lung Cancer (NSCLC)
Colorectal Cancer (CRC)
Drug: RMC-6236
Drug: RMC-9805

Phase 1

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 16 other locations

This first-in-human study will evaluate safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of PHN-012,...

Enrolling
Advanced Cancer
Colon Cancer
Drug: PHN-012

Phase 1

Pheon Therapeutics

Durham, North Carolina, United States and 25 other locations

The purpose of this study is to assess the safety and tolerability of XmAb®819 administered intravenous (IV) or subcutaneous (SC) in subjects with re...

Enrolling
Clear Cell Renal Cell Carcinoma
Biological: XmAb819

Phase 1

Xencor
Xencor

Durham, North Carolina, United States and 26 other locations

the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...

Enrolling
Stage III Colon Cancer
Drug: mFOLFOX6 3-6 month
Device: Signatera test

Phase 2, Phase 3

NRG Oncology
NRG Oncology

Durham, North Carolina, United States and 1076 other locations

The main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally ad...

Active, not recruiting
Non-small Cell Lung Cancer
Colorectal Cancer
Drug: Pembrolizumab
Drug: Irinotecan

Phase 1

Lilly
Lilly

Durham, North Carolina, United States and 46 other locations

chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer....

Enrolling
CRC (Colorectal Cancer)
Drug: INCA33890
Drug: Placebo

Phase 3

Incyte
Incyte

Chapel Hill, North Carolina, United States and 282 other locations

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