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provide a better understanding of study drugs cetuximab (Erbitux®) and palbociclib when used in combination to treat patients with metastatic colon...
Phase 2
Chapel Hill, North Carolina, United States
(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Durham, North Carolina, United States and 212 other locations
The purpose of this study is to examine if Nivolumab by itself, or Nivolumab in combination with other anti-cancer drugs, will result in mea ...
Phase 2
Durham, North Carolina, United States and 32 other locations
with histologically or cytologically confirmed stage IV colorectal cancer coming form three different patient populations:Cohort 1a: 6 patie...
Phase 1
Durham, North Carolina, United States and 11 other locations
with panitumumab in subjects with unresectable, refractory, KRAS/NRAS/BRAF wild-type, microsatellite stable (MSS) metastatic colorectal cancer...
Phase 2
Chapel Hill, North Carolina, United States and 4 other locations
This is an open-label, two-part, phase 1-2 study designed to determine the safety, tolerability, PK, pharmacodynamics (PD), and proof-of-concept effi...
Phase 1
Durham, North Carolina, United States and 4 other locations
to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer...
Phase 1, Phase 2
Chapel Hill, North Carolina, United States and 83 other locations
the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon...
Phase 2, Phase 3
Durham, North Carolina, United States and 827 other locations
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with adva...
Phase 1, Phase 2
Chapel Hill, North Carolina, United States and 97 other locations
To assess:efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification,...
Phase 2
Chapel Hill, North Carolina, United States and 90 other locations
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