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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
London, United Kingdom and 250 other locations
A significant proportion of patients who undergo liver surgery to remove bowel cancer that has spread to the liver (metastases) develop dise...
Phase 3
London, United Kingdom and 12 other locations
This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor ...
Phase 1, Phase 2
London, United Kingdom and 84 other locations
oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor...
Phase 1, Phase 2
London, Greater London, United Kingdom and 25 other locations
This study will test the safety of a drug called PF-08046052/SGN-EGFRd2 in participants with advanced solid tumors. It will also study the s...
Phase 1
London, United Kingdom and 12 other locations
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody ta...
Phase 1
London, United Kingdom and 33 other locations
trial is to determine the safety and efficacy of IP-001 for intratumoral injection administration following thermal ablation of a solid tumor...
Phase 1, Phase 2
London, United Kingdom and 15 other locations
known as MVC-101) in adults with unremovable advanced or metastatic cancer. Another aim is to characterize and evaluate the activity of TAK-...
Phase 1, Phase 2
London, Middlesex, United Kingdom and 27 other locations
pembrolizumab or irinotecan that can be given to patients who have cancers with specific molecular alterations called MSIhi (Microsatellite ...
Phase 1
London, United Kingdom and 27 other locations
Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET...
Phase 2
London, United Kingdom and 90 other locations
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