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using liquid biopsy to guide the post-surgical and post-adjuvant clinical management in 140 microsatellite stable Stage-III and T4N0 Stage-II colon...
Phase 2
Milan, Italy and 10 other locations
cohort of HER2+ RAS wild-type colon cancer patients will be assessed for ct-DNA clearance after a tailored treatment with Trastuzu...
Phase 2
Milan, Italy and 27 other locations
(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Milano, Lombardia, Italy and 212 other locations
and pembrolizumab) given together for the treatment of colorectal cancer that:is metastatic (spread to other parts of the body);has the cond...
Phase 2
Milano, Italy and 108 other locations
to participants with advanced solid tumors, including rearranged during transfection (RET)-fusion-positive solid tumors, medullary thyroid cancer...
Phase 1, Phase 2
Milano, Lombardie, Italy and 83 other locations
in combination with pembrolizumab in patients with select advanced cancers, and to identify the maximum tolerated dose and/or recommended do...
Phase 1
Milano, MI, Italy and 12 other locations
This is an open-label, multi-center Phase 1/2 study of oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET...
Phase 1, Phase 2
Milan, Lombardia, Italy and 25 other locations
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of escalating doses of RMC-6291 (KRAS G12C(ON) inhibitor...
Phase 1
Milano, Italy and 63 other locations
plus BSC in participants with refractory metastatic colorectal cancer (mCRC). 691 participants were randomized to one of the following treat...
Phase 3
Milano, ITA, Italy and 152 other locations
tislelizumab or irinotecan that can be given to patients who have cancers with specific molecular alterations called MSIhi (Microsatellite I...
Phase 1
Rozzano, MI, Italy and 18 other locations
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