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(SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instability high (dMMR/MSI-H) colon...
Phase 3
Wynnewood, Pennsylvania, United States and 250 other locations
doses of selected chemotherapies will be safe and tolerable for cancer patients with advanced solid tumors. The highest tolerated d...
Phase 1
Philadelphia, Pennsylvania, United States and 3 other locations
The purpose of this study is to examine if Nivolumab by itself, or Nivolumab in combination with other anti-cancer drugs, will result in mea ...
Phase 2
Allentown, Pennsylvania, United States and 31 other locations
This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor ...
Phase 1, Phase 2
Philadelphia, Pennsylvania, United States and 83 other locations
RSC-101 is a Phase 1a/1b clinical trial of RSC-1255 in adult study participants with advanced solid tumor malignancies who are intolerant of...
Phase 1
Philadelphia, Pennsylvania, United States and 4 other locations
oral LOXO-292 in pediatric participants with an activating rearranged during transfection (RET) alteration and an advanced solid or primary CNS tumor...
Phase 1, Phase 2
Philadelphia, Pennsylvania, United States and 25 other locations
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor...
Phase 2, Phase 3
Philadelphia, Pennsylvania, United States and 878 other locations
This is a first-in-human, open-label, non-randomized, three-part phase 1 trial of INBRX-109, which is a recombinant humanized tetravalent antibody ta...
Phase 1
Philadelphia, Pennsylvania, United States and 18 other locations
of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with advanced solid tumors...
Phase 1, Phase 2
Philadelphia, Pennsylvania, United States and 8 other locations
This open-label study will evaluate the safety, tolerability, pharmacokinetics and effect on tumor growth following a single intralesional i...
Phase 1
Bethlehem, Pennsylvania, United States and 4 other locations
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