Researchers are looking for other ways to prevent severe illness from COVID-19. COVID-19 is a virus that most often causes mild flu or cold-like symptoms. However, people with certain health conditions or other factors have a high risk (chance) of getting severely ill from COVID-19, which can require a hospital stay or lead to death. Some people who are high risk for severe illness may be unable to take certain treatments for COVID-19 because they are not available to them, or they take other medicines that may react with a treatment and cause an unwanted effect.

Molnupiravir (MK-4482) is a study medicine designed to stop the COVID-19 virus from copying itself in the body (multiplying). The goal of this study is to learn if molnupiravir prevents severe illness from COVID-19 more than placebo in people who are high risk.

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

Cullman, AL

Georgia Office

Farmington Hills, MI

Charlotte, NC

Monroe, NC

Orlando, FL

Tampa, FL

Shadow Creek - Pearland, TX

Miami Lakes, FL

Miami, FL

Coral Gables, FL

Corpus Christi, TX

Laredo Laguna

Los Alamitos, CA

Northridge, CA

Redmond, WA

Lima, Peru

Kyiv, Ukraine

Bucharest, Romania

Auckland, New Zealand

Pacific Clinical Research Network - Tasman

Merck Sharp & Dohme (MSD)

The purpose of the study is to evaluate whether ibuzatrelvir is effective and safe in adults and adolescents with COVID-19 who do not need to be in the hospital but who are at high risk for progression to severe disease. Eligible participants will be randomly assigned (by chance) to receive ibuzatrelvir or matching placebo orally for 5 days. Co-administration of locally available standard of care is allowed. The total duration of the study is around 6 months.

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

Nashville, TN

Columbus, OH

Little Rock, AR

Kennedy Street NW, Washington

Jessica Waters

Hinesville, GA

DeLand, FL

Dallas, TX

Clearwater, FL

Medicine Department - Rheumatology Division

Houston, TX

Fort Myers, FL

Fort Lauderdale, FL

Pembroke Pines, FL

Hialeah, FL

Doral, FL

AMR Coral Gables, FL

Homestead, FL

Clinton, UT

Butte, MT

JM Research SC

Pretoria, South Africa

Long Beach, CA

IdiPAZ - Hemato-Oncologia Pediatrica

Clinical Research Unit

Namur, Belgium

Cologne, Germany

Berlin, Germany

Radomyšl, Czech Republic

Protivin, Czech Republic

Hořiněves, Czech Republic

Ceske Budejovice, Czech Republic

Brno, Czech Republic

Haskovo, Bulgaria

Johannesburg, South Africa

Durban, South Africa

Pfizer

The purpose of this study is to evaluate the efficacy and safety of mRNA-1283 and mRNA-1273 (variant formulations) in adults 50 to 64 years of age without high risk factors for severe COVID-19.

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

Derby City Direct Primary Care - Louisville, KY

Cincinnati, OH

Magnolia Family Medicine

Ms. Medicine - Amy Roberts MD and Associates

Chesterfield, MO

Springer Wellness and Restorative Health

Atlanta, GA

Accel Research Sites - NeuroStudies

Stockbridge, GA

Command Family Medicine - Springfield

Forest Avenue, Richmond, VA

Lenexa, KY

Mount Pleasant, SC

Newton Family Medicine

Rochester, NY

Grassroots Healthcare - Tulsa, OK

The Murphy Clinic - Mandeville, LA

Lincoln, NE

New Orleans, LA

Neighborhood Health - Prairieville, LA

Commons Circle

Bridgeport, CT

Zomnir Family Medicine - Prosper, TX

Maitland, FL

Jupiter, FL

Round Rock, TX

West Gate Boulevard

Fort Collins

JBR Clinical Research

Riverside, CA

San Diego, CA

Rolling Hills Estates, CA

Portland, OR

Moderna

The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

AstraZeneca

The purpose of this study is to evaluate safety and efficacy of risankizumab in participants with ulcerative colitis (UC) in participants who responded to induction treatment with risankizumab in a prior AbbVie study of risankizumab in UC.

This study consists of three sub-studies and a Continuous Treatment Extension (CTE): Substudy 1 is a 52-week, randomized, double-blind, placebo-controlled maintenance study; Substudy 2 is 52-week, randomized, exploratory maintenance study; and Substudy 3 is an open-label long-term extension study for participants who completed Substudy 1 or 2, or participants who responded to induction treatment in Study M16-067 with no final endoscopy due to the Covid-19 pandemic or due to the geopolitical conflict in Ukraine and surrounding impacted regions. The CTE is an open-label extension for Substudy 3 completers to ensure continuous treatment with risankizumab until such time that risankizumab becomes commercially available and/or the subject can access treatment locally.

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

Optimed Research, LTD

Rheumatology

Mentor, OH

Gastrointestinal Research and Clinical Trial Center of Georgia

Omaha, NE

Shreveport, LA

North Bay, Canada

Tyler, TX

New Port Richey, FL

Omega Research Orlando, LLC

Site Coordinator

Victoria Gastroenterology

San Antonio, TX

Clinical Protocols Department

Ophthalmology, Ogden, UT

United Clinical Research - Los Alamitos

Smidt Heart Institute

Los Angeles, CA

New Westminster, Canada

UCSF Center for Colitis and Crohn's Disease

Medicina Interna - Ensayos Clinicos

Ematologia Clinical Trials Unit

Bydgoszcz, Poland

Gastroenterology Department

Department of Gastroenterology

Gastroenterology

Complejo Asistencial Dr. Sotero Del Rio - Investigaciones Medicas SSMSO Office

Centro de Investigacion en Oncologia

Clinical Research Center - Oncology Department

The Helmsley Cancer Center - Oncological Day Hospital

Nagoya City University Hospital

Cardiology Clinical Trials Unit

Dunedin Hospital - Gastroenterology Research Unit

AbbVie

The study consists of 4 sub-studies, as follows:

* Sub-study 1 (Randomized, double-blind, placebo controlled study) to evaluate the efficacy and safety of risankizumab versus placebo as maintenance therapy in participants with moderately to severely active Crohn's disease (CD) who responded to intravenous risankizumab induction treatment in Study M16-006 or Study M15-991;
* Sub-study 2 (Randomized, exploratory maintenance study) to evaluate the efficacy and safety of two different dosing regimens for risankizumab as maintenance therapy in participants who responded to induction treatment in Study M16-006 or Study M15-991;
* Sub-study 3 (Open-label, long-term extension study) to evaluate long-term safety of risankizumab in participants who completed Sub-study 1, Sub-study 2, another AbbVie risankizumab Crohn's disease study, or participants who responded to induction treatment in Study M16-006 or Study M15-991 with no final endoscopy due to the Covid-19 pandemic. Additional objectives are to further investigate long-term efficacy and tolerability of risankizumab;
* Sub-study 4 (Open-label On Body Injector (OBI) administration and long-term extension study) to evaluate patient-reported outcomes, efficacy, safety, tolerability, and pharmacokinetics of risankizumab administered via OBI in participants who are receiving maintenance treatment with risankizumab.
* OL CTE to ensure uninterrupted care in accordance with local regulations until risankizumab is commercially available for participants who completed Sub-study 3, Sub-study 4.

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease

Find clinical trials for COVID-19 in Louisville, KY

Related conditions:

COVID-19 trials near Louisville, KY, USA:

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) (MOVe-NOW)

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis (COMMAND)

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease (FORTIFY)

Find clinical trials for COVID-19 in .css-epvm6{white-space:nowrap;}Louisville, KY

Related conditions:

COVID-19 trials near Louisville, KY, USA:

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023) (MOVe-NOW)

A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen (TILIA)

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis (COMMAND)

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease (FORTIFY)

Find clinical trials for COVID-19 in Louisville, KY