The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine tablet VXA-CoV2-3.3 compared to a currently recommended vaccine for the prevention of symptomatic Coronavirus Disease 2019 (COVID-19).

In order to represent a more recently circulating SARS-CoV-2 variant, the main study endpoints will now evaluate the VXA-CoV2-3.3 (KP.2 strain) vaccine, and not the VXA-CoV2-3.1 (XBB.1.5 strain) vaccine.

A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection

Austin, TX

Commons Circle

Lenexa, KY

Anniston, AL

Cincinnati, OH

Doral, FL

Miami, FL

North Miami Beach, FL

Newport News, VA

Baltimore, MD

Sacramento, CA

Waterbury, MA

Vaxart

The purpose of this clinical trial is to learn about the safety, pharmacokinetics (pharmacokinetics helps us understand how the drug is changed and eliminated from your body after you take it), and efficacy (how well a study treatment works in the study) of the study medicine (called nirmatrelvir/ritonavir) for potential treatment of coronavirus disease 2019 (COVID-19).

The study medicine will be given to patients under 18 years of age with COVID-19 that are not hospitalized but are at risk for severe disease.

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

McAllen, TX

Clinical Research Support Unit | Mexico City, United States

Veracruz, Mexico

JM Research SC

Florida Pulmonary Research Institute, LLC

Summerville, SC

Medicine Department - Rheumatology Division

Trujillo Alto, PR

Benoni, South Africa

Pfizer

The purpose of this study is to evaluate the efficacy and safety of mRNA-1283 and mRNA-1273 (variant formulations) in adults 50 to 64 years of age without high risk factors for severe COVID-19.

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

West Gate Boulevard

Round Rock, TX

Zomnir Family Medicine - Prosper, TX

Neighborhood Health - Prairieville, LA

Grassroots Healthcare - Tulsa, OK

New Orleans, LA

The Murphy Clinic - Mandeville, LA

Command Family Medicine - Springfield

Cullman, AL

Chesterfield, MO

Ms. Medicine - Amy Roberts MD and Associates

Lincoln, NE

Magnolia Family Medicine

Fort Collins

Atlanta, GA

Springer Wellness and Restorative Health

Stockbridge, GA

Accel Research Sites - NeuroStudies

Derby City Direct Primary Care - Louisville, KY

Tampa, FL

Maitland, FL

DeLand, FL

JBR Clinical Research

Newton Family Medicine

Mount Pleasant, SC

San Diego, CA

Jupiter, FL

Miami Lakes, FL

Riverside, CA

Rolling Hills Estates, CA

Forest Avenue, Richmond, VA

Rochester, NY

Bridgeport, CT

Portland, OR

Moderna

There is a pressing need to increase capacity to treat PTSD related to or exacerbated by the COVID-19 pandemic. Texting-based therapy holds promise to increase capacity and reduce barriers to delivering evidence-based treatments (EBTs), but ongoing engagement in digital mental health interventions is low. This study will compare a texting-based EBT for PTSD to culturally-informed texting-based treatment for PTSD as usual, and it will also compare a unique incentive strategy to typical platform reminders aimed to prevent early discontinuation in therapy. This online study is open to individuals who live in 18 different states.

Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD

Stanford University

The purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a Novartis ofatumumab clinical MS study.

Vaccination sub-study The purpose of this research sub-study is to find out the effects of ofatumumab on the development of antibody responses to selected vaccines and keyhole limpet hemocyanin (KLH) neo-antigen in subjects with relapsing multiple sclerosis (RMS).

COVID-19 sub-study:

The purpose of this research sub-study is to explore the immune response following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccination in a subset of subjects on long-term ofatumumab 20 mg sc. Note: Novartis is not supplying the SARS-CoV-2 vaccine.

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Houston, TX

Pensacola, FL

Colorado Springs, CO

Boulder, CO

Office of Clinical Trials

Clearwater, FL

Bradenton, FL

Port Charlotte, FL

Naples, FL

Ormond Beach, FL

Savannah, GA

Northbrook, IL

Hollywood, FL

Westerville, OH

Raleigh, NC

Wellesley, MA

Neuro-Life

Novartis

The purpose of this study is to evaluate safety and efficacy of risankizumab in participants with ulcerative colitis (UC) in participants who responded to induction treatment with risankizumab in a prior AbbVie study of risankizumab in UC.

This study consists of three sub-studies and a Continuous Treatment Extension (CTE): Substudy 1 is a 52-week, randomized, double-blind, placebo-controlled maintenance study; Substudy 2 is 52-week, randomized, exploratory maintenance study; and Substudy 3 is an open-label long-term extension study for participants who completed Substudy 1 or 2, or participants who responded to induction treatment in Study M16-067 with no final endoscopy due to the Covid-19 pandemic or due to the geopolitical conflict in Ukraine and surrounding impacted regions. The CTE is an open-label extension for Substudy 3 completers to ensure continuous treatment with risankizumab until such time that risankizumab becomes commercially available and/or the subject can access treatment locally.

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis

San Antonio, TX

Site Coordinator

Victoria Gastroenterology

Tyler, TX

Shreveport, LA

Clinical Protocols Department

Omaha, NE

Gastrointestinal Research and Clinical Trial Center of Georgia

New Port Richey, FL

Omega Research Orlando, LLC

Orlando, FL

Ophthalmology, Ogden, UT

Optimed Research, LTD

Rheumatology

United Clinical Research - Los Alamitos

Smidt Heart Institute

Los Angeles, CA

Mentor, OH

UCSF Center for Colitis and Crohn's Disease

North Bay, Canada

PerCuro Victoria

New Westminster, Canada

Complejo Asistencial Dr. Sotero Del Rio - Investigaciones Medicas SSMSO Office

Centro de Investigacion en Oncologia

Medicina Interna - Ensayos Clinicos

Clinical Research Center - Oncology Department

IdiPAZ - Hemato-Oncologia Pediatrica

Clinical Research Unit

Ematologia Clinical Trials Unit

Bydgoszcz, Poland

Department of Gastroenterology

Gastroenterology Department

Gastroenterology

Nagoya City University Hospital

The Helmsley Cancer Center - Oncological Day Hospital

Cardiology Clinical Trials Unit

Dunedin Hospital - Gastroenterology Research Unit

AbbVie

The study consists of 4 sub-studies, as follows:

* Sub-study 1 (Randomized, double-blind, placebo controlled study) to evaluate the efficacy and safety of risankizumab versus placebo as maintenance therapy in participants with moderately to severely active Crohn's disease (CD) who responded to intravenous risankizumab induction treatment in Study M16-006 or Study M15-991;
* Sub-study 2 (Randomized, exploratory maintenance study) to evaluate the efficacy and safety of two different dosing regimens for risankizumab as maintenance therapy in participants who responded to induction treatment in Study M16-006 or Study M15-991;
* Sub-study 3 (Open-label, long-term extension study) to evaluate long-term safety of risankizumab in participants who completed Sub-study 1, Sub-study 2, another AbbVie risankizumab Crohn's disease study, or participants who responded to induction treatment in Study M16-006 or Study M15-991 with no final endoscopy due to the Covid-19 pandemic. Additional objectives are to further investigate long-term efficacy and tolerability of risankizumab;
* Sub-study 4 (Open-label On Body Injector (OBI) administration and long-term extension study) to evaluate patient-reported outcomes, efficacy, safety, tolerability, and pharmacokinetics of risankizumab administered via OBI in participants who are receiving maintenance treatment with risankizumab.
* OL CTE to ensure uninterrupted care in accordance with local regulations until risankizumab is commercially available for participants who completed Sub-study 3, Sub-study 4.

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease

Find clinical trials for COVID-19 in San Antonio, TX

Related conditions:

COVID-19 trials near San Antonio, TX, USA:

A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD (CPT-TEXT)

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS (ALITHIOS)

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis (COMMAND)

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease (FORTIFY)

Find clinical trials for COVID-19 in .css-epvm6{white-space:nowrap;}San Antonio, TX

Related conditions:

COVID-19 trials near San Antonio, TX, USA:

A Study to Evaluate VXA-CoV2-3.3 COVID-19 Vaccine Against Currently Approved/Authorized mRNA COVID-19 Injectable Booster Vaccine in Adults Previously Immunized Against COVID-19 Infection

EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

A Study to Evaluate the Efficacy and Safety of mRNA-1283 and mRNA-1273 in Participants 50 to 64 Years of Age Without High-Risk Conditions for Severe Coronavirus Disease 2019 (COVID-19)

Telehealth 2.0: Evaluating Effectiveness and Engagement Strategies for CPT-Text for PTSD (CPT-TEXT)

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS (ALITHIOS)

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Ulcerative Colitis (COMMAND)

A Study of the Efficacy and Safety of Risankizumab in Participants With Crohn's Disease (FORTIFY)

Find clinical trials for COVID-19 in San Antonio, TX