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Find clinical trials for Endometrial Cancer in Durham, NC

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Ovarian Cancer
Non-Small-Cell Lung Carcinoma
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Uterine Cervical Cancer
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Endometrial Cancer trials near Durham, NC, USA:

Signatera Assessment in Early-Stage Endometrial Cancer (SIGNAL-EMC 101)

The goal of this clinical trial is to assess if circulating tumor DNA can guide adjuvant selection in high-intermediate risk early-stage endometrial...

Not yet enrolling
Endometrial Cancer
Device: Signatera Genome ultra-sensitive ctDNA blood test
Natera
Natera

Durham, North Carolina, United States and 8 other locations

This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune check ...

Enrolling
Endometrial Cancer
Drug: Talazoparib
Drug: Atezolizumab - 21 Day Cycle

Phase 1, Phase 2

Alliance Foundation Trials

Durham, North Carolina, United States and 20 other locations

Endometrial cancer (EC) is the fourth most common cancer in United States women, and alarmingly, the frequency and mortali...

Enrolling
Endometrial Cancer
Clear Cell Endometrial Carcinoma
Drug: ONC201
Drug: Atezolizumab

Phase 1

UNC Lineberger Comprehensive Cancer Center
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States of America

This is a multicenter, open-label, nonrandomized, Phase 2 umbrella study of retifanlimab in participants who have advanced or metastatic endometrial...

Active, not recruiting
Endometrial Cancer
Drug: INCAGN02385
Drug: pemigatinib

Phase 2

Incyte
Incyte

Chapel Hill, North Carolina, United States of America and 66 other locations

Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with plati...

Active, not recruiting
Endometrial Cancer
Drug: Paclitaxel
Drug: Rescue medications

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Durham, North Carolina, United States and 242 other locations

participants with recurrent or primary advanced (Stage III or IV) endometrial cancer....

Active, not recruiting
Neoplasms
Drug: Paclitaxel
Drug: Carboplatin

Phase 3

Tesaro
Tesaro

Durham, North Carolina, United States and 168 other locations

drug LY3484356 alone or in combination with other anticancer therapies is safe and effective in participants with advanced or metastatic breast cancer...

Active, not recruiting
Endometrial Cancer
Breast Cancer
Drug: Trastuzumab
Drug: Everolimus

Phase 1

Lilly
Lilly

Durham, North Carolina, United States and 73 other locations

Locations recently updated

to evaluate the efficacy and safety of ACR-368 as monotherapy or with ultra-low dose gemcitabine (ULDG) sensitization in participants with endometrial...

Enrolling
Endometrial Adenocarcinoma
Drug: ACR-368
Diagnostic Test: OncoSignature

Phase 2

Acrivon Therapeutics

Chapel Hill, North Carolina, United States and 89 other locations

Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advance...

Enrolling
Endometrial Cancer
Drug: Carboplatin
Biological: Pembrolizumab

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Durham, North Carolina, United States and 245 other locations

who have the appropriate human leukocyte antigen (HLA) and MAGE-A4 tumor antigen. Tumor indications include endometrial, e....

Active, not recruiting
Endometrial Cancer
Esophageal Cancer
Genetic: Autologous genetically modified ADP-A2M4CD8 cells alone or in combination with nivolumab every four weeks or pembrolizumab every 6 weeks

Phase 1

USWM CT, LLC

Durham, North Carolina, United States and 16 other locations

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