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Find clinical trials for Endometrial Cancer in Pittsburgh, PA

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Colorectal Cancer
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Uterine Cervical Cancer
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Endometrial Cancer trials near Pittsburgh, PA, USA:

Signatera Assessment in Early-Stage Endometrial Cancer (SIGNAL-EMC 101)

The goal of this clinical trial is to assess if circulating tumor DNA can guide adjuvant selection in high-intermediate risk early-stage endometrial...

Not yet enrolling
Endometrial Cancer
Device: Signatera Genome ultra-sensitive ctDNA blood test
Natera
Natera

Pittsburgh, Pennsylvania, United States and 11 other locations

The purpose of this study is to investigate the efficacy and safety of the lifileucel regimen in participants with previously treated endometrial...

Enrolling
Endometrial Cancer
Biological: Lifileucel

Phase 2

Iovance Biotherapeutics

Pittsburgh, Pennsylvania, United States and 11 other locations

and safety of T-DXd adjuvant therapy, with or without radiotherapy, post-surgery in anticancer treatment naïve (including neoadjuvant therapy) endometrial...

Enrolling
Endometrial Cancer
Drug: Trastuzumab Deruxtecan
Drug: Chemotherapy

Phase 3

Daiichi Sankyo
Daiichi Sankyo

Pittsburgh, Pennsylvania, United States and 85 other locations

study to evaluate the efficacy and safety of sapanisertib and serabelisib (PIKTOR) with paclitaxel in participants with advanced or recurrent endometrial...

Enrolling
Endometrial Cancer
Drug: Serabelisib
Drug: Paclitaxel

Phase 2

Faeth Therapeutics

Pittsburgh, Pennsylvania, United States and 17 other locations

This is a Phase III, 2-arm, randomized, open label, multicenter, global study assessing the efficacy and safety of puxitatug samrotecan compared to p...

Enrolling
Endometrial Cancer
Malignant Solid Tumour
Drug: Puxitatug Samrotecan
Drug: Paclitaxel

Phase 3

AstraZeneca
AstraZeneca

Pittsburgh, Pennsylvania, United States and 318 other locations

This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune check ...

Enrolling
Endometrial Cancer
Drug: Talazoparib
Drug: Atezolizumab - 21 Day Cycle

Phase 1, Phase 2

Alliance Foundation Trials

Pittsburgh, Pennsylvania, United States and 20 other locations

Researchers are looking for new ways to treat people with endometrial cancer (EC) who have previously received treatment with plati...

Active, not recruiting
Endometrial Cancer
Drug: Paclitaxel
Drug: Rescue medications

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Pittsburgh, Pennsylvania, United States and 243 other locations

This phase II clinical trial studies the effect of lenvatinib, pembrolizumab, and paclitaxel in treating patients with endometrial, epitheli...

Active, not recruiting
Recurrent Endometrial Carcinoma
Recurrent Primary Peritoneal Carcinoma
Biological: Pembrolizumab
Drug: Paclitaxel

Phase 2

Floor Backes, MD

Pittsburgh, Pennsylvania, United States and 1 other location

DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when com...

Enrolling
Endometrial Cancer
Drug: Carboplatin
Drug: Paclitaxel

Phase 3

AstraZeneca
AstraZeneca

Pittsburgh, Pennsylvania, United States and 255 other locations

(paclitaxel + carboplatin) followed by maintenance durvalumab with or without olaparib for patients with newly diagnosed advanced or recurrent endometrial...

Active, not recruiting
Endometrial Neoplasms
Drug: Carboplatin
Biological: durvalumab

Phase 3

AstraZeneca
AstraZeneca

Pittsburgh, Pennsylvania, United States and 201 other locations

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