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Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II....
Phase 2, Phase 3
Aurora, Colorado, United States and 61 other locations
OKN-007 combined with temozolomide(TMZ) in patients with recurrent glioblastoma(GBM). All patients will have been previously treate...
Phase 2
Englewood, Colorado, United States and 12 other locations
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...
Aurora, Colorado, United States and 132 other locations
receptor (EGFR) resistance (EGFR C797S) mutations with or without CNS disease (in Phase 1 and Phase 2), or glioblastoma (GBM) expr...
Phase 1, Phase 2
Denver, Colorado, United States and 24 other locations
This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...
Phase 1, Phase 2
Denver, Colorado, United States and 10 other locations
This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an...
Phase 1, Phase 2
Denver, Colorado, United States and 19 other locations
This study will investigate different doses of \[177Lu\]Lu-NeoB in combination with RT and TMZ in participants with newly diagnosed glioblastoma...
Phase 1
Aurora, Colorado, United States and 14 other locations
This is an open-label, multicenter, randomized, parallel, 2-arm, efficacy and safety study. Patients with GBM after failure of standard firs...
Phase 2
Englewood, Colorado, United States and 47 other locations
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