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Find clinical trials for Glioblastoma (GBM) in Cleveland, OH

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Related conditions:

Glioblastoma
Glioma
Brain Cancer
Cancer
Recurrence
Astrocytoma
Gliosarcoma

Glioblastoma (GBM) trials near Cleveland, OH, USA:

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

The purpose of this study is to see if combining silevertinib with temozolomide after surgery and radiotherapy helps treat newly diagnosed glioblastoma...

Enrolling
Glioblastoma (GBM)
Newly Diagnosed Glioblastoma
Drug: temozolomide (TMZ)
Drug: silevertinib in combination with temozolomide

Phase 2

Black Diamond Therapeutics

Cleveland, Ohio, United States and 29 other locations

This study will investigate different doses of \[177Lu\]Lu-NeoB in combination with RT and TMZ in participants with newly diagnosed glioblastoma...

Active, not recruiting
Newly Diagnosed and Recurrent Glioblastoma
Other: Temozolomide
Drug: [68Ga]Ga-NeoB

Phase 1

Novartis
Novartis

Cleveland, Ohio, United States and 15 other locations

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II...

Enrolling
Glioblastoma
Drug: Regorafenib
Drug: Temozolomide

Phase 2, Phase 3

Global Coalition for Adaptive Research

Cleveland, Ohio, United States and 62 other locations

the return of cancer in patients with a newly diagnosed or recurrent glioblastoma multiforme (GBM) in combination with standard che...

Active, not recruiting
Glioblastoma
Biological: Allogeneic genetically modified gamma-delta T cells
Biological: Autologous genetically modified gamma-delta T cells

Phase 1, Phase 2

In8bio

Cleveland, Ohio, United States and 4 other locations

Optune® together with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the stud...

Enrolling
Glioblastoma
Drug: Temozolomide
Drug: Placebo

Phase 3

NovoCure
NovoCure

Cleveland, Ohio, United States and 101 other locations

This multi-site, Phase 1/2a clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen o...

Active, not recruiting
Glioblastoma Multiforme
Drug: Perillyl alcohol

Phase 1, Phase 2

NeOnc Technologies

Cleveland, Ohio, United States and 10 other locations

This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM).The drugs involved in ...

Enrolling
Glioblastoma
Drug: Neratinib
Drug: CC-115

Phase 2

David Reardon, MD

Cleveland, Ohio, United States and 11 other locations

are also impermeable to the passage of therapeutic molecules from the blood to the brain. The development of effective treatments against glioblastoma...

Enrolling
Glioblastoma
Recurrent Glioblastoma
Device: SonoCloud-9 (SC9)
Drug: Temozolomide

Phase 3

Carthera

Cleveland, Ohio, United States and 55 other locations

The purpose of this study is to establish the recommended phase 2 dose of eflornithine in combination with temozolomide in patients whose glioblastoma...

Enrolling
Glioblastoma
Glioblastoma Multiforme
Drug: Temozolomide
Drug: Eflornithine (Dose Level 2)

Phase 1

Orbus Therapeutics

Cleveland, Ohio, United States and 7 other locations

(TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main question it aims to ans...

Active, not recruiting
Glioblastoma
GBM
Drug: Niraparib
Drug: Temozolomide

Phase 3

Ivy Brain Tumor Center

Cleveland, Ohio, United States and 94 other locations

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