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The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM...
Phase 3
Cleveland, Ohio, United States and 85 other locations
Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II....
Phase 2, Phase 3
Cleveland, Ohio, United States and 60 other locations
This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblastoma (GBM) or other recurrent glioma...
Phase 2
Cleveland, Ohio, United States and 80 other locations
This is a Phase 1 dose-escalation study of PRT3645, a Cyclin-dependent Kinase 4/6 (CDK4/6) inhibitor, in patients with advanced or metastatic solid t...
Phase 1
Cleveland, Ohio, United States and 12 other locations
The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by a chemical change)....
Phase 3
Cleveland, Ohio, United States and 122 other locations
the return of cancer in patients with a newly diagnosed or recurrent glioblastoma multiforme (GBM) in combination with standard che...
Phase 1, Phase 2
Cleveland, Ohio, United States and 6 other locations
This research study is studying several investigational drugs as a possible treatment for Glioblastoma (GBM).The drugs involved in ...
Phase 2
Cleveland, Ohio, United States and 11 other locations
This multi-site, Phase 1/2a clinical trial is an open label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen o...
Phase 1, Phase 2
Cleveland, Ohio, United States and 5 other locations
The purpose of this study is to establish the recommended phase 2 dose of eflornithine in combination with temozolomide in patients whose glioblastoma...
Phase 1
Cleveland, Ohio, United States and 7 other locations
This is a phase 2 study of oncolytic polio/rhinovirus recombinant (PVSRIPO) in adult patients with recurrent World Health Organization (WHO) grade IV...
Phase 2
Cleveland, Ohio, United States and 5 other locations
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