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Find clinical trials for Glioblastoma (GBM) in Durham, NC

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Related conditions:

Glioblastoma
Brain Cancer
Glioma
Cancer
Recurrence
Astrocytoma
Gliosarcoma

Glioblastoma (GBM) trials near Durham, NC, USA:

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

efficacy of INO-5401 and INO-9012 in combination with cemiplimab (REGN2810), with radiation and chemotherapy, in subjects with newly-diagnosed glioblastoma...

Active, not recruiting
Glioblastoma
Drug: Temozolomide
Biological: INO-9012

Phase 1, Phase 2

Inovio Pharmaceuticals
Inovio Pharmaceuticals

Chapel Hill, North Carolina, United States and 20 other locations

(SOC) will improve survival in adult patients newly diagnosed with glioblastoma (IDH-wt). It will also evaluate the safety of DOC1021 + pIFN...

Enrolling
Glioblastoma (GBM)
Drug: Temodar (Temozolomide)
Biological: DOC1021

Phase 2

Diakonos Oncology Corporation

Chapel Hill, North Carolina, United States and 15 other locations

lerapolturev in the subcutaneous area (under the skin) around the lymph nodes of the head and neck for adult patients diagnosed with recurrent glioblastoma...

Enrolling
Recurrent Supratentorial Glioblastoma
Drug: Lerapolturev
Drug: Lomustine Pill

Phase 2

Darell Bigner

Durham, North Carolina, United States

Recently updated

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II...

Enrolling
Glioblastoma
Drug: Regorafenib
Drug: Temozolomide

Phase 2, Phase 3

Global Coalition for Adaptive Research

Durham, North Carolina, United States and 62 other locations

Optune® together with maintenance TMZ and placebo in newly diagnosed Glioblastoma (GBM) patients. The primary objective of the stud...

Enrolling
Glioblastoma
Drug: Temozolomide
Drug: Placebo

Phase 3

NovoCure
NovoCure

Durham, North Carolina, United States and 90 other locations

The purpose of this study is to assess progression-free survival (PFS) and overall survival (OS) in newly diagnosed Glioblastoma (GBM...

Active, not recruiting
Glioblastoma
Combination Product: IGV-001 Cell Immunotherapy
Drug: SOC: Temozolomide

Phase 2

Imvax

Chapel Hill, North Carolina, United States and 22 other locations

Locations recently updated

are also impermeable to the passage of therapeutic molecules from the blood to the brain. The development of effective treatments against glioblastoma...

Enrolling
Glioblastoma
Recurrent Glioblastoma
Device: SonoCloud-9 (SC9)
Drug: Temozolomide

Phase 3

Carthera

Chapel Hill, North Carolina, United States and 48 other locations

growth factor receptor (EGFR) resistance (EGFR C797S) mutations with or without CNS disease (in Phase 1 and Phase 2), or glioblastoma (GBM...

Active, not recruiting
Advanced Non-Small Cell Squamous Lung Cancer
Epidermal Growth Factor Receptor C797S
Drug: silevertinib (BDTX-1535) monotherapy

Phase 1, Phase 2

Black Diamond Therapeutics

Chapel Hill, North Carolina, United States and 28 other locations

The purpose of this study is to establish the recommended phase 2 dose of eflornithine in combination with temozolomide in patients whose glioblastoma...

Enrolling
Glioblastoma
Glioblastoma Multiforme
Drug: Temozolomide
Drug: Eflornithine (Dose Level 2)

Phase 1

Orbus Therapeutics

Durham, North Carolina, United States and 7 other locations

(TMZ) in adult participants with newly-diagnosed, MGMT unmethylated glioblastoma multiforme (GBM). The main question it aims to ans...

Enrolling
Glioblastoma
GBM
Drug: Niraparib
Drug: Temozolomide

Phase 3

Ivy Brain Tumor Center

Durham, North Carolina, United States and 94 other locations

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