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Find clinical trials for Glioblastoma (GBM) in Durham, NC

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Related conditions:

Glioblastoma
Recurrence
Brain Cancer
Glioma
Cancer
Astrocytoma
Gliosarcoma

Glioblastoma (GBM) trials near Durham, NC, USA:

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

efficacy of INO-5401 and INO-9012 in combination with cemiplimab (REGN2810), with radiation and chemotherapy, in subjects with newly-diagnosed glioblastoma...

Active, not recruiting
Glioblastoma
Drug: Temozolomide
Biological: INO-9012

Phase 1, Phase 2

Inovio Pharmaceuticals
Inovio Pharmaceuticals

Chapel Hill, North Carolina, United States and 20 other locations

lerapolturev in the subcutaneous area (under the skin) around the lymph nodes of the head and neck for adult patients diagnosed with recurrent glioblastoma...

Enrolling
Recurrent Supratentorial Glioblastoma
Drug: Lerapolturev
Drug: Lomustine Pill

Phase 2

Darell Bigner

Durham, North Carolina, United States

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II....

Enrolling
Glioblastoma
Drug: Temozolomide
Radiation: Radiation

Phase 2, Phase 3

Global Coalition for Adaptive Research

Durham, North Carolina, United States and 61 other locations

The purpose of this first-in-human (FIH) study of \[177Lu\]-NeoB is to characterize the safety, tolerability, pharmacokinetics (PK) as well as the di...

Enrolling
Neoplasms
Drug: [68Ga]-NeoB
Drug: LCZ696

Phase 1, Phase 2

Advanced Accelerator Applications

Durham, North Carolina, United States and 13 other locations

The purpose of this study is to assess progression-free survival (PFS) and overall survival (OS) in newly diagnosed Glioblastoma (GBM...

Active, not recruiting
Glioblastoma
Combination Product: IGV-001 Cell Immunotherapy
Drug: SOC: Temozolomide

Phase 2

Imvax

Chapel Hill, North Carolina, United States and 22 other locations

are also impermeable to the passage of therapeutic molecules from the blood to the brain. The development of effective treatments against glioblastoma...

Enrolling
Glioblastoma
Recurrent Glioblastoma
Device: SonoCloud-9 (SC9)
Drug: Temozolomide

Phase 3

Carthera

Chapel Hill, North Carolina, United States and 22 other locations

To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...

Active, not recruiting
Glioblastoma Multiforme
Device: Optune®
NovoCure
NovoCure

Chapel Hill, North Carolina, United States and 132 other locations

The purpose of this study is to establish the recommended phase 2 dose of eflornithine in combination with temozolomide in patients whose glioblastoma...

Enrolling
Glioblastoma
Glioblastoma Multiforme
Drug: Temozolomide
Drug: Eflornithine (Dose Level 2)

Phase 1

Orbus Therapeutics

Durham, North Carolina, United States and 7 other locations

This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...

Active, not recruiting
Glioblastoma
Glioblastoma Multiforme
Drug: ST101
Drug: Temozolomide

Phase 1, Phase 2

Sapience Therapeutics

Durham, North Carolina, United States and 10 other locations

This is a phase 2 study of oncolytic polio/rhinovirus recombinant (PVSRIPO) in adult patients with recurrent World Health Organization (WHO) grade IV...

Active, not recruiting
Malignant Glioma
Biological: PVSRIPO

Phase 2

Istari Oncology

Durham, North Carolina, United States and 5 other locations

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