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The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM...
Phase 3
Nashville, Tennessee, United States and 85 other locations
This is an open-label, monotherapy study of pemigatinib in participants with recurrent glioblastoma (GBM) or other recurrent glioma...
Phase 2
Nashville, Tennessee, United States and 80 other locations
This is a Phase 1 dose-escalation study of PRT3645, a Cyclin-dependent Kinase 4/6 (CDK4/6) inhibitor, in patients with advanced or metastatic solid t...
Phase 1
Nashville, Tennessee, United States and 12 other locations
The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by a chemical change)....
Phase 3
Nashville, Tennessee, United States and 122 other locations
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...
Nashville, Tennessee, United States and 132 other locations
The purpose of this study is to assess the safety and tolerability of VBI-1901 in subjects with recurrent malignant gliomas (glioblastoma, o...
Phase 1, Phase 2
Nashville, Tennessee, United States and 10 other locations
This is an open-label, two-part, phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy o...
Phase 1, Phase 2
Nashville, Tennessee, United States and 11 other locations
This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an...
Phase 1, Phase 2
Nashville, Tennessee, United States and 11 other locations
To evaluate the safety and tolerability of escalating doses of ERAS-801 in study participants with recurrent glioblastoma multiforme (GBM...
Phase 1
Nashville, Tennessee, United States and 7 other locations
Researchers are looking for a better way to treat people with solid tumors. Before a treatment can be approved for people to take, researchers do cli...
Phase 2
Nashville, Tennessee, United States and 33 other locations
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