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The primary purpose of the study is to determine the efficacy of an investigational therapy called DCVax(R)-L in patients with newly diagnosed GBM...
Phase 3
Saint Louis, Missouri, United States and 85 other locations
Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II....
Phase 2, Phase 3
Saint Louis, Missouri, United States and 60 other locations
with or without epacadostat in the treatment of recurrent glioblastoma (GBM). The investigators hypothesize that this combination p...
Phase 2
Saint Louis, Missouri, United States and 3 other locations
The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by a chemical change)....
Phase 3
Saint Louis, Missouri, United States and 122 other locations
therapy in subjects with newly diagnosed, MGMT promoter unmethylated glioblastoma (GBM).Immune checkpoint blockade, specifically th...
Phase 1
Saint Louis, Missouri, United States
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...
Saint Louis, Missouri, United States and 132 other locations
This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an...
Phase 1, Phase 2
Saint Louis, Missouri, United States and 11 other locations
receptor (EGFR) resistance (EGFR C797S) mutations with or without CNS disease (in Phase 1 and Phase 2), or glioblastoma multiforme (GBM...
Phase 1, Phase 2
Saint Louis, Missouri, United States and 25 other locations
To assess:efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification,...
Phase 2
Saint Louis, Missouri, United States and 90 other locations
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