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Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/II....
Phase 2, Phase 3
Saint Louis, Missouri, United States and 61 other locations
with or without epacadostat in the treatment of recurrent glioblastoma (GBM). The investigators hypothesize that this combination p...
Phase 2
Saint Louis, Missouri, United States and 3 other locations
therapy in subjects with newly diagnosed, MGMT promoter unmethylated glioblastoma (GBM).Immune checkpoint blockade, specifically th...
Phase 1
Saint Louis, Missouri, United States
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM...
Saint Louis, Missouri, United States and 132 other locations
receptor (EGFR) resistance (EGFR C797S) mutations with or without CNS disease (in Phase 1 and Phase 2), or glioblastoma (GBM) expr...
Phase 1, Phase 2
Saint Louis, Missouri, United States and 24 other locations
This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an...
Phase 1, Phase 2
Saint Louis, Missouri, United States and 18 other locations
To assess:* efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification...
Phase 2
Saint Louis, Missouri, United States and 90 other locations
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