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Find clinical trials for Heart Disease in Durham, NC

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Related conditions:

Heart Diseases
Cardiovascular Diseases
Heart Failure
Coronary Artery Disease
Myocardial Ischemia
Aortic Valve Stenosis
Heart Valve Diseases

Heart Disease trials near Durham, NC, USA:

Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure (INNOVATE)

non-inferiority to the HeartMate 3 Left Ventricular Assist System when used for the treatment of advanced, refractory, left ventricular heart...

Enrolling
Cardiovascular Diseases
Heart Failure
Device: BrioVAD System
Device: HeartMate 3
BrioHealth Solutions, Inc.

Durham, North Carolina, United States and 46 other locations

The study will evaluate the impact of a combined device-drug strategy with Impella 5.5 with best practices and optimized GDMT on heart recov...

Not yet enrolling
Heart Failure
Reduced Ejection Fraction Heart Failure
Device: Impella 5.5 SmartAssist
Abiomed
Abiomed

Durham, North Carolina, United States and 14 other locations

of the Cordella™ Pulmonary Artery Sensor System in NYHA Class II-III Heart Failure Patients (PROACTIVE-HF-2 Trial).The study contains of 5 a...

Enrolling
Heart Failure NYHA Class II
Heart Failure NYHA Class III
Device: Cordella™ Pulmonary Artery Sensor System
Endotronix

Durham, North Carolina, United States and 50 other locations

evaluating the safety and efficacy of dual chamber personalized pacing compared to minimal or no pacing for the treatment of patients with heart...

Enrolling
Heart Failure With Preserved Ejection Fraction (HFpEF)
Device: Personalized cardiac pacing
Medtronic
Medtronic

Durham, North Carolina, United States and 49 other locations

safety and effectiveness of the HeartMate 3 LVAS compared to guideline directed medical therapy (GDMT) in a population of ambulatory advanced heart...

Enrolling
Cardiovascular Diseases
Heart Failure
Other: Guideline Medical Directed Therapy
Device: HeartMate 3 Left Ventricular Assist System
Abbott
Abbott

Chapel Hill, North Carolina, United States and 67 other locations

This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo...

Enrolling
Single Ventricle Heart Disease
Drug: Placebo
Drug: Udenafil

Phase 3

Mezzion Pharmaceuticals

Durham, North Carolina, United States and 39 other locations

Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device.

Enrolling
Mitral Valve Regurgitation
Device: Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Covidien
Covidien

Durham, North Carolina, United States and 84 other locations

Prospective, single-arm, multi-center, continued access study of the Autus Size-Adjustable Valve in pediatric patients aged 18 months to 16 years req...

Enrolling
Congenital Heart Disease
Device: Pulmonary Valve Replacement Surgery
Edwards Lifesciences
Edwards Lifesciences

Durham, North Carolina, United States and 9 other locations

Prospective, single-arm, multi-center study to evaluate safety and effectiveness of the Autus Size-Adjustable Valve in pediatric patients aged 18 mon...

Active, not recruiting
Congenital Heart Disease
Device: Pulmonary Valve Replacement Surgery
Edwards Lifesciences
Edwards Lifesciences

Durham, North Carolina, United States and 11 other locations

VictORION-INCLUSION (V-INCLUSION) seeks to evaluate the effectiveness of inclisiran as an innovative therapy with the potential to help bridge care g...

Active, not recruiting
Atherosclerotic Cardiovascular Disease
Drug: Inclisiran

Phase 4

Duke University
Duke University

Durham, North Carolina, United States and 24 other locations

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