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Find clinical trials for Heart Disease in St Louis, MO

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Related conditions:

Heart Diseases
Coronary Artery Disease
Cardiovascular Diseases
Heart Failure
Myocardial Ischemia
Coronary Disease
Hypertension

Heart Disease trials near St Louis, MO, USA:

A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 and MAS825 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Clonal Hematopoiesis of Indeterminate Potential (CHIP)

of MAS825, to reduce key markers of inflammation related to CVD risk, such as IL-6 and IL-18, in approximately 28 people with known coronary heart...

Active, not recruiting
Coronary Heart Disease
Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Drug: DFV890
Drug: DFV890 placebo

Phase 2

Novartis
Novartis

Saint Louis, Missouri, United States and 5 other locations

is intended to assess the ability of AZD3427 to reduce pulmonary vascular resistance (PVR) after 24 weeks of treatment in participants with heart...

Enrolling
Heart Failure
Pulmonary Hypertension (World Health Organization Group 2)
Drug: AZD3427
Drug: Placebo

Phase 2

AstraZeneca
AstraZeneca

Saint Louis, Missouri, United States and 64 other locations

The purpose of this study is to evaluate the device performance and monitor the safety and effectiveness of the Berlin Heart EXCOR Active Dr...

Enrolling
Transplant; Failure, Heart
Congenital Heart Disease
Device: EXCOR Active Driving System for Pediatric VAD
Berlin Heart

Saint Louis, Missouri, United States and 10 other locations

The goal of this clinical trial is to validate performance claims for method comparison for ABL90 FLEX PLUS in heparinized neonatal arterial, venous,...

Enrolling
Congenital Heart Disease
Device: method comparison
Radiometer

Saint Louis, Missouri, United States

The purpose of this study is to characterize the functionality of transcatheter implantation of the Medtronic Harmony Transcatheter Pulmonary Valve (...

Enrolling
Congenital Heart Disease
Tetrology of Fallot
Device: Harmony TPV System
Covidien
Covidien

Saint Louis, Missouri, United States and 20 other locations

To demonstrate the safety and effectiveness of the Edwards Alterra Adaptive Prestent in conjunction with the Edwards SAPIEN 3 Transcatheter Heart...

Active, not recruiting
Pulmonary Disease
Congenital Heart Disease
Device: Edwards Alterra Adaptive Prestent with SAPIEN 3 THV
Edwards Lifesciences
Edwards Lifesciences

Saint Louis, Missouri, United States and 13 other locations

To assess the safety and effectiveness of the SAPIEN 3 transcatheter heart valve in patients with a failing mitral bioprosthetic valve....

Active, not recruiting
Mitral Valve Disease
Heart Failure
Device: Edwards SAPIEN 3 transcatheter valve, Model 9600TFX
Edwards Lifesciences
Edwards Lifesciences

Saint Louis, Missouri, United States and 11 other locations

This study will evaluate the clinical efficacy and safety of udenafil, an orally administered, potent and selective inhibitor of PDE5, versus placebo...

Enrolling
Single Ventricle Heart Disease
Drug: Placebo
Drug: Udenafil

Phase 3

Mezzion Pharmaceuticals

Saint Louis, Missouri, United States and 27 other locations

Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Ph...

Invitation-only
Ischemic Heart Disease
Coronary Artery Disease
Device: Philips SyncVision system with Philips pressure wires
Procedure: standard of care angiographically-guided PCI
Philips
Philips

Saint Louis, Missouri, United States and 82 other locations

To collect information about treatment for symptomatic severe Aortic Regurgitation (AR), which affects the aortic valve in the heart. Aortic...

Active, not recruiting
Aortic Valve Disease
Aortic Insufficiency
Device: JenaValve Trilogy Heart Valve System
JenaValve Technology

Saint Louis, Missouri, United States and 29 other locations

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