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Find clinical trials for Heart Disease in Toronto, ON

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Related conditions:

Heart Diseases
Coronary Artery Disease
Cardiovascular Diseases
Myocardial Ischemia
Heart Failure
Coronary Disease
Hypertension

Heart Disease trials near Toronto, ON, CAN:

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2 (Re-PHIRE)

is intended to assess the ability of AZD3427 to reduce pulmonary vascular resistance (PVR) after 24 weeks of treatment in participants with heart...

Enrolling
Heart Failure
Pulmonary Hypertension (World Health Organization Group 2)
Drug: AZD3427
Drug: Placebo

Phase 2

AstraZeneca
AstraZeneca

Toronto, Ontario, Canada and 63 other locations

A multicenter, randomized clinical trial to assess whether catheter ablation or antiarrhythmic drug therapy provides the most effective control of im...

Active, not recruiting
Ventricular Tachycardia (VT)
Procedure: Catheter ablation
Drug: Antiarrythmic Drug Therapy

Phase 4

John Sapp

Toronto, Ontario, Canada and 20 other locations

Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Ph...

Invitation-only
Ischemic Heart Disease
Coronary Artery Disease
Device: Philips SyncVision system with Philips pressure wires
Procedure: standard of care angiographically-guided PCI
Philips
Philips

Toronto, Canada and 71 other locations

The purpose of this study is to further evaluate the safety and effectiveness of the Harmony™ TPV system. The Pivotal/CAS phases of the study have tr...

Active, not recruiting
Congenital Heart Disease
Tetrology of Fallot
Device: Harmony TPV System
Medtronic
Medtronic

Toronto, Ontario, Canada and 11 other locations

This study will evaluate the safety and effectiveness of the Edwards SAPIEN 3/SAPIEN 3 Ultra Transcatheter Heart Valve (THV) compared with c...

Active, not recruiting
Heart Diseases
Aortic Stenosis, Severe
Device: Edwards SAPIEN 3 / SAPIEN 3 Ultra THV
Edwards Lifesciences
Edwards Lifesciences

Toronto, Ontario, Canada and 76 other locations

The researchers are doing this study to look whether the type 2 diabetes medicine, semaglutide, has a positive effect on heart disease...

Active, not recruiting
Diabetes Mellitus, Type 2
Drug: Semaglutide
Drug: Placebo (semaglutide)

Phase 3

Novo Nordisk
Novo Nordisk

Toronto, Ontario, Canada and 467 other locations

Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device.

Enrolling
Mitral Valve Regurgitation
Device: Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)
Covidien
Covidien

Toronto, Ontario, Canada and 84 other locations

The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with...

Enrolling
Persistent Atrial Fibrillation
Device: FARAPULSE™ Pulsed Field Ablation (PFA) System
Drug: Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, and Dofetilide
Boston Scientific
Boston Scientific

Hamilton, Ontario, Canada and 49 other locations

This is a prospective, multi-center, randomized, controlled, patient- and evaluator-blinded study comparing treatment with the CardiAMP cell therapy...

Active, not recruiting
Heart Failure, Systolic
Other: Sham
Biological: Autologous cell therapy

Phase 3

BioCardia

Toronto, Ontario, Canada and 25 other locations

2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart...

Enrolling
Coronary Artery Disease
Left Ventricular Dysfunction
Device: Impella CP® / Impella CP® with SmartAssist® / Impella 2.5®
Device: IABP Intra-aortic balloon pump
Abiomed
Abiomed

Toronto, Ontario, Canada and 122 other locations

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