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Find clinical trials for Heart Disease in Toronto, ON

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Related conditions:

Heart Diseases
Coronary Artery Disease
Cardiovascular Diseases
Heart Failure
Myocardial Ischemia
Coronary Disease
Aortic Valve Stenosis

Heart Disease trials near Toronto, ON, CAN:

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2 (Re-PHIRE)

is intended to assess the ability of AZD3427 to reduce pulmonary vascular resistance (PVR) after 24 weeks of treatment in participants with heart...

Enrolling
Heart Failure
Pulmonary Hypertension (World Health Organization Group 2)
Drug: AZD3427
Drug: Placebo

Phase 2

AstraZeneca
AstraZeneca

Toronto, Ontario, Canada and 64 other locations

The objective of ENVISION is to evaluate the safety and effectiveness of the Navitor Transcatheter Aortic Valve Implantation (TAVI) System for treati...

Invitation-only
Heart Valve Diseases
Aortic Valve Disease
Device: Navitor Transcatheter Aortic Valve Implantation (TAVI) System
Device: Any Commercially Available Transcatheter Aortic Valve (CAV) System
Abbott
Abbott

Toronto, Ontario, Canada and 61 other locations

Familial Hypercholesterolemia (HeFH) or Premature Coronary Artery Disease (CAD) Who Require Additional Lowering of LDL-C. VERVE-102 Uses Bas...

Enrolling
Premature Coronary Heart Disease
Heterozygous Familial Hypercholesterolemia
Drug: VERVE-102

Phase 1

Verve Therapeutics

Toronto, Canada and 7 other locations

The purpose of this study is to further evaluate the safety and effectiveness of the Harmony™ TPV system. The Pivotal/CAS phases of the study have tr...

Active, not recruiting
Congenital Heart Disease
Tetrology of Fallot
Device: Harmony TPV System
Medtronic
Medtronic

Toronto, Ontario, Canada and 11 other locations

Multi-center, prospective, randomized controlled study comparing PCI guided by angiography versus iFR Co-Registration using commercially available Ph...

Invitation-only
Ischemic Heart Disease
Coronary Artery Disease
Device: Philips SyncVision system with Philips pressure wires
Procedure: standard of care angiographically-guided PCI
Philips
Philips

Toronto, Canada and 82 other locations

with placebo in reducing the risk of the clinical consequences of AKI (MAKE) at 90 days in adult participants with CKD who undergo non-emergent cardiac...

Enrolling
Chronic Kidney Disease
Cardiac Disease
Drug: Placebo
Drug: Ravulizumab

Phase 3

Alexion Pharmaceuticals
Alexion Pharmaceuticals

Toronto, Ontario, Canada and 195 other locations

A multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on recurrence of a...

Enrolling
Atrial Fibrillation
Other: Aggressive Risk Factor Control
Other: Standard of Care
Nova Scotia Health Authority (NSHA)

Toronto, Ontario, Canada and 16 other locations

This is a prospective, multi-center, randomized, controlled, patient- and evaluator-blinded study comparing treatment with the CardiAMP cell therapy...

Active, not recruiting
Heart Failure, Systolic
Biological: Autologous cell therapy
Other: Sham

Phase 3

BioCardia

Toronto, Ontario, Canada and 25 other locations

of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart...

Enrolling
Cardiovascular Diseases
Heart Failure Preserved Ejection Fraction
Drug: Placebo
Drug: Tovinontrine (CRD-750

Phase 2

Cardurion Pharmaceuticals

Hamilton, Ontario, Canada and 58 other locations

of this study is to evaluate the safety and effectiveness of tovinontrine compared to placebo to lower NT-proBNP in patients with chronic heart...

Enrolling
Cardiovascular Diseases
Heart Failure With Reduced Ejection Fraction
Drug: Tovinontrine (CRD-750)
Drug: Placebo

Phase 2

Cardurion Pharmaceuticals

Hamilton, Ontario, Canada and 70 other locations

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