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A) or REGN5458 (Part B) as monotherapy in patients with chronic kidney disease (CKD) who need kidney transplantation and a...
Phase 1, Phase 2
New Haven, Connecticut, United States and 7 other locations
ObjectivesTo assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV)To characterize the pharmacokinetic (PK) properties...
Phase 1
New Haven, Connecticut, United States and 27 other locations
to evaluate efficacy, safety and tolerability of treatment with zibotentan/dapagliflozin and dapagliflozin alone in participants with chronic kidney...
Phase 3
Hamden, Connecticut, United States and 321 other locations
tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney...
Phase 2, Phase 3
New Haven, Connecticut, United States and 236 other locations
compared with dapagliflozin alone on patients with chronic kidney disease (CKD) and albuminuria. This study will evaluate the effec...
Phase 2
Waterbury, Connecticut, United States and 94 other locations
Primary Objective:Evaluate the effect of Hectorol® capsules in reducing elevated levels of intact parathyroid hormone (iPTH).Secondary Objectives:Eva...
Phase 3
New Haven, Connecticut, United States and 29 other locations
Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial ...
Phase 3
New Haven, Connecticut, United States and 312 other locations
The primary objective of this study is to assess the efficacy of a single dose of ravulizumab IV compared with placebo in reducing the risk of the cl...
Phase 3
Valhalla, New York, United States and 173 other locations
receptor is known to trigger injury and inflammation in the kidney and is therefore thought to play a role in CKD.Empagliflozin lowers blood...
Phase 2
Waterbury, Massachusetts, United States of America and 210 other locations
This is a 2-part (phase 2b/3) prospective, interventional, multicenter, randomized, double blind, placebo controlled study. Part 1 (phase 2b) is a do...
Phase 2, Phase 3
Middlebury, Connecticut, United States and 60 other locations
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