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This study evaluates whether it is safe to administer a peptide vaccine made of 6MHP and a mutated neoantigen peptide (BRAF585-614-V600E) combined wi...
Phase 1, Phase 2
Cleveland, Ohio, United States and 1 other location
efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma...
Phase 3
Cleveland, Ohio, United States of America and 37 other locations
Approximately 40 participants with locally advanced or metastatic melanoma will be enrolled in 20 sites in the United States into 1 of the f...
Phase 2
Cleveland, Ohio, United States and 12 other locations
antigen (HLA)-A*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotini...
Phase 2, Phase 3
Cleveland, Ohio, United States and 62 other locations
to assess nivolumab plus relatlimab fixed-dose combination (FDC) versus nivolumab alone in participants with completely resected stage III-IV melanoma...
Phase 3
Cleveland, Ohio, United States and 171 other locations
Part 1 is the dose escalation of APG-115 in combination with label dose of pembrolizumab.Part 2 is phase II design of APG-115 at recommended phase 2...
Phase 1, Phase 2
Cleveland, Ohio, United States and 19 other locations
not worse than nivolumab + relatlimab FDC intravenous (IV) administration in participants with previously untreated metastatic or unresectable melanoma...
Phase 3
Cleveland, Ohio, United States and 189 other locations
and pediatric participants after complete resection of Stage IIB/C melanoma with no evidence of disease (NED) who are at high risk for recur...
Phase 3
Cleveland, Ohio, United States and 128 other locations
treatment compared to pembrolizumab in patients that have had melanoma removal surgery but are still at high risk for the recurrence of the...
Phase 3
Cleveland, Ohio, United States and 195 other locations
(PROs) of autogene cevumeran (RO7198457) plus pembrolizumab compared with pembrolizumab alone in patients with previously untreated advanced melanoma...
Phase 2
Cleveland, Ohio, United States and 56 other locations
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