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Find clinical trials for Melanoma in St Louis, MO

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Melanoma trials near St Louis, MO, USA:

A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

cell death protein-1 (PD-1) inhibitor, in patients with metastatic melanomas or advanced solid tumors. Our hypothesis is that restoration of...

Enrolling
Mucosal Melanoma
Melanoma
Drug: Phase 1b: APG-115+pembrolizumab

Phase 1, Phase 2

Ascentage Pharma Group
Ascentage Pharma Group

Saint Louis, Missouri, United States and 20 other locations

and overall survival (OS) for patients with NRAS-mutant (NRASm) melanoma who are randomized to receive the combination of naporafenib + tram...

Enrolling
Advanced or Metastatic NRAS-mutant Melanoma
Drug: Trametinib
Drug: Naporafenib

Phase 3

Erasca

Saint Louis, Missouri, United States and 44 other locations

Locations recently updated

efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma...

Enrolling
Ocular Melanoma
Choroidal Melanoma
Device: Suprachoroidal Microinjector
Drug: Bel-sar

Phase 3

Aura Biosciences
Aura Biosciences

Saint Louis, Missouri, United States and 46 other locations

sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with Nivolumab in subjects with unresectable and metastatic melanoma...

Enrolling
Mucosal Melanoma
Melanoma Stage IV
Drug: Nivolumab
Drug: [212Pb]VMT01

Phase 1, Phase 2

Perspective Therapeutics

Saint Louis, Missouri, United States and 9 other locations

participants with a type of skin cancer known as melanoma.The objective of this study is to see if the combination of fianlimab and cemipli...

Enrolling
Melanoma
Drug: pembrolizumab
Drug: cemiplimab

Phase 2, Phase 3

Regeneron Pharmaceuticals
Regeneron Pharmaceuticals

Saint Louis, Missouri, United States and 12 other locations

To evaluate the overall survival of HLA-A\*0201 positive adult patients with previously untreated advanced UM receiving IMCgp100 compared to Investig...

Active, not recruiting
Uveal Melanoma
Biological: IMCgp100
Biological: Pembrolizumab

Phase 2

Immunocore
Immunocore

Saint Louis, Missouri, United States and 55 other locations

antigen (HLA)-A\*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotin...

Enrolling
Metastatic Uveal Melanoma
Drug: IDE196
Drug: Nivolumab

Phase 2, Phase 3

Ideaya Biosciences

Saint Louis, Missouri, United States and 65 other locations

treatment of adult subjects with completely treated high-risk ocular melanoma, as defined in eligibility criteria, without evidence of metas...

Active, not recruiting
Melanoma
Ocular Melanoma
Drug: Ipilimumab
Drug: Nivolumab

Phase 2

Suthee Rapisuwon

Saint Louis, Missouri, United States and 5 other locations

combined with nivolumab in patients with unresectable or metastatic melanoma. A separate open-label cohort of adults with new, progressive b...

Active, not recruiting
Unresectable or Metastatic Melanoma
Progressive Brain Metastasis
Drug: Placebo in combination with nivolumab
Drug: HBI-8000 in combination with nivolumab

Phase 3

HUYABIO

Bridgeton, Missouri, United States and 138 other locations

and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in participants with complete resection of cutaneous melanoma...

Enrolling
Melanoma
Drug: mRNA-4157
Biological: Pembrolizumab

Phase 2

Moderna
Moderna

Saint Louis, Missouri, United States and 20 other locations

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