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emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated in patients with unresectable and metastatic melanoma...
Phase 1, Phase 2
Saint Louis, Missouri, United States and 8 other locations
To evaluate the overall survival of HLA-A*0201 positive adult patients with previously untreated advanced UM receiving IMCgp100 compared to Investiga...
Phase 2
Saint Louis, Missouri, United States and 55 other locations
antigen (HLA)-A*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotini...
Phase 2, Phase 3
Saint Louis, Missouri, United States and 62 other locations
treatment of adult subjects with completely treated high-risk ocular melanoma, as defined in eligibility criteria, without evidence of metas...
Phase 2
Saint Louis, Missouri, United States and 5 other locations
Part 1 is the dose escalation of APG-115 in combination with label dose of pembrolizumab.Part 2 is phase II design of APG-115 at recommended phase 2...
Phase 1, Phase 2
Saint Louis, Missouri, United States and 19 other locations
combined with nivolumab on patients with unresectable or metastatic melanoma and eligible patients who are not adolescents or patients with ...
Phase 3
Bridgeton, Missouri, United States and 141 other locations
and pembrolizumab improves recurrence free survival (RFS) compared to pembrolizumab alone in participants with complete resection of cutaneous melanoma...
Phase 2
Saint Louis, Missouri, United States and 20 other locations
The purpose of this study is to determine whether nivolumab is better than ipilimumab to prevent recurrence of melanoma....
Phase 3
Saint Louis, Missouri, United States and 135 other locations
(PROs) of autogene cevumeran (RO7198457) plus pembrolizumab compared with pembrolizumab alone in patients with previously untreated advanced melanoma...
Phase 2
Saint Louis, Missouri, United States and 56 other locations
belvarafenib as a single agent and in combination with either cobimetinib or cobimetinib plus nivolumab in patients with NRAS-mutant advanced melanoma...
Phase 1
Saint Louis, Missouri, United States and 23 other locations
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