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Find clinical trials for Multiple Myeloma in Durham, NC

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Related conditions:

Plasma Cell Cancer
Lymphoma
Hematologic Cancer
Cancer
Leukemia
Smoldering Multiple Myeloma
Non-Hodgkin Lymphoma

Multiple Myeloma trials near Durham, NC, USA:

A Study to Evaluate 3 Dose Schedules of Daratumumab in Participants With Smoldering Multiple Myeloma

The purpose of this study is to evaluate three daratumumab dose schedules in participants with Smoldering Multiple Myeloma....

Active, not recruiting
Multiple Myeloma
Drug: daratumumab

Phase 2

Janssen (J&J Innovative Medicine)

Chapel Hill, North Carolina, United States and 56 other locations

lenalidomide and dexamethasone for the treatment of newly diagnosed multiple myeloma (MM). The study team will use lower doses than...

Enrolling
Multiple Myeloma
Cancer
Drug: Lenalidomide
Drug: Isatuximab

Phase 2

UNC Lineberger Comprehensive Cancer Center
UNC Lineberger Comprehensive Cancer Center

Durham, North Carolina, United States and 2 other locations

This study is designed as a phase I-II, open label, dose finding study.Study treatment will be as follows, in 28 day cycles:* Pomalidomide: once dail...

Active, not recruiting
Multiple Myeloma
Drug: Bendamustine
Drug: Dexamethasone

Phase 1, Phase 2

Cristina Gasparetto

Durham, North Carolina, United States

of these combinations in participants with relapsed or refractory multiple myeloma. The study will consist of 3 distinct parts: Par ...

Active, not recruiting
Multiple Myeloma
Drug: Bortezomib
Drug: Daratumumab

Phase 2

AbbVie
AbbVie

Durham, North Carolina, United States and 39 other locations

A Phase 2, open-label, dose escalation study to evaluate the safety and efficacy of venetoclax in combination with carfilzomib-dexamethasone (Kd) in...

Active, not recruiting
Multiple Myeloma
Drug: Venetoclax
Drug: Dexamethasone

Phase 2

AbbVie
AbbVie

Durham, North Carolina, United States and 31 other locations

phases, for the treatment of patients with relapsed/refractory multiple myeloma (RRMM) and newly diagnosed multiple myeloma...

Active, not recruiting
Multiple Myeloma
Drug: Mezigdomide
Drug: Ixazomib

Phase 1, Phase 2

Karyopharm Therapeutics
Karyopharm Therapeutics

Durham, North Carolina, United States and 18 other locations

versus standard regimens in subjects with relapsed and refractory multiple myeloma (RRMM).The study is anticipated to randomize app...

Active, not recruiting
Multiple Myeloma
Drug: Dexamethasone
Drug: Carfilzomib

Phase 3

Celgene
Celgene

Durham, North Carolina, United States and 59 other locations

This study is a first-in-human, Phase 1, open-label study that will evaluate safety and anti-myeloma activity of ISB 2001 in participants wi ...

Enrolling
Relapsed/Refractory Multiple Myeloma
Drug: ISB 2001

Phase 1

Ichnos Sciences

Chapel Hill, North Carolina, United States and 5 other locations

This is a phase 1, open-label study evaluating the safety, clinical pharmacology and clinical activity of TNB-383B, a BCMA x CD3 T-cell engaging bisp...

Active, not recruiting
Multiple Myeloma
Drug: TNB-383B

Phase 1, Phase 2

TeneoOne

Chapel Hill, North Carolina, United States and 13 other locations

versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) followed by Autologous Stem Cell Transplant (ASCT) in newly diagnosed multiple...

Enrolling
Multiple Myeloma
Drug: Fludarabine
Drug: Daratumumab

Phase 3

Stichting European Myeloma Network

Durham, North Carolina, United States and 126 other locations

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