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Find clinical trials for Non-Small-Cell Lung Cancer in Charlotte, NC

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Related conditions:

Non-Small-Cell Lung Carcinoma
Lung Cancer
Colorectal Cancer
Cancer
Neoplasm Metastasis
Squamous Cell Carcinoma of Head and Neck
Melanoma

Non-Small-Cell Lung Cancer trials near Charlotte, NC, USA:

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

This study is designed to evaluate the antitumor activity of patritumab deruxtecan in participants with metastatic or locally advanced NSCLC with an...

Active, not recruiting
Non-Small Cell Lung Cancer Metastatic
Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
Drug: Patritumab Deruxtecan (Fixed dose)
Drug: Patritumab Deruxtecan (Up-Titration)

Phase 2

Daiichi Sankyo
Daiichi Sankyo

Charlotte, North Carolina, United States and 123 other locations

antitumor activity of STX-721/PFL-721 in participants with non-small cell lung cancer (NSCLC) carrying E...

Enrolling
Non-Small Cell Lung Cancer
EGFR/HER2 Exon 20 Insertion Mutation
Drug: STX-721/PFL-721 with platinum-based chemotherapy
Drug: STX-721/PFL-721 (Escalated) with platinum-based chemotherapy

Phase 1, Phase 2

Pierre Fabre
Pierre Fabre

Charlotte, North Carolina, United States and 31 other locations

This study is open to adults 18 years and older with advanced or metastatic non-small cell lung cancer. ...

Active, not recruiting
Lung Cancer, Non-squamous, Non-small Cell
Drug: carboplatin
Drug: zongertinib

Phase 3

Boehringer Ingelheim
Boehringer Ingelheim

Rock Hill, South Carolina, United States and 162 other locations

(SG), versus docetaxel in participants with advanced or metastatic (cancer that has spread) non-small cell lung...

Active, not recruiting
Non-Small Cell Lung Cancer
Biological: Sacituzumab Govitecan-hziy (SG)
Drug: Docetaxel

Phase 3

Gilead Sciences
Gilead Sciences

Charlotte, North Carolina, United States and 227 other locations

This is a single-arm, single-stage Phase II study designed to evaluate the 1-year PFS rate in subjects with locally-advanced NSCLC (stage II/III) and...

Active, not recruiting
Non Small Cell Lung Cancer
Lung Cancer Stage III
Drug: Paclitaxel
Drug: Durvalumab

Phase 2

Wake Forest University (WFU)
Wake Forest University (WFU)

Charlotte, North Carolina, United States

versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or...

Active, not recruiting
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Biological: Pembrolizumab
Biological: Ramucirumab

Phase 3

SWOG Cancer Research Network
SWOG Cancer Research Network

Charlotte, North Carolina, United States and 566 other locations

The purpose of this study is to evaluate izalontamab brengitecan (iza-bren) combined with osimertinib in participants with previously untreated, loca...

Enrolling
Non-Small Cell Lung Cancer
Drug: Cisplatin
Drug: Iza-bren

Phase 3

Bristol-Myers Squibb (BMS)
Bristol-Myers Squibb (BMS)

Charlotte, North Carolina, United States and 203 other locations

This phase II/III Expanded Lung-MAP treatment trial compares the effect of adding cemiplimab to docetaxel and ramucirumab versus docetaxel a-...

Enrolling
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Drug: Docetaxel
Procedure: Biospecimen Collection

Phase 2, Phase 3

SWOG Cancer Research Network
SWOG Cancer Research Network

Gaffney, South Carolina, United States and 412 other locations

resected Stage II, IIIA, IIIB (with nodal involvement \[N2\]) non-small cell lung cancer (NSCLC). The pr...

Active, not recruiting
Non-small Cell Lung Cancer
Other: Placebo
Biological: Intismeran autogene

Phase 3

Merck Sharp & Dohme (MSD)
Merck Sharp & Dohme (MSD)

Charlotte, North Carolina, United States and 229 other locations

This study will assess the efficacy and safety of the combination of ceralasertib and durvalumab versus standard of care docetaxel in patients with l...

Active, not recruiting
Advanced or Metastatic Non-Small Cell Lung Cancer
Drug: Durvalumab
Drug: Ceralasertib

Phase 3

AstraZeneca
AstraZeneca

Charlotte, North Carolina, United States and 190 other locations

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