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to determine the safety and preliminary evidence of a therapeutic effect of azeliragon in patients refractory to prior treatment of metastatic pancreatic...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 5 other locations
ONIVYDE + LV + 5-FU chemotherapy regimen in patients with advanced pancreatic cancer and to determine the recommended dose for the ...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 27 other locations
and clinical activity of AB680 in combination with zimberelimab (AB122), nab-paclitaxel and gemcitabine in participants with advanced pancreatic...
Phase 1
Pittsburgh, Pennsylvania, United States and 17 other locations
The study is a multi-center, open-label, randomized active controlled study of subjects with locally advanced pancreatic adenocarcinoma whic...
Phase 3
Pittsburgh, Pennsylvania, United States and 41 other locations
and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers...
Phase 2
Pittsburgh, Pennsylvania, United States and 65 other locations
administered orally as monotherapy in patients with advanced solid tumors with gene alterations in the RAS- MAPK pathway for whom there are ...
Phase 1
Pittsburg, Pennsylvania, United States and 14 other locations
of care. It is being tested against advanced and/or metastatic solid tumors including gastric, gastroesophageal junction, pancreatic...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 17 other locations
This is a study of the combination of 9 ING-41 (elraglusib) and retifanlimab plus mFOLFIRINOX in patients with pancreatic cancer wi...
Phase 1
Pittsburgh, Pennsylvania, United States
This is a first in human (FIH) 2-part study using ACTM-838 in patients with advanced solid tumors resistant to standard of care treatment. P...
Phase 1
Pittsburgh, Pennsylvania, United States and 4 other locations
, metastatic castration-resistant prostate cancer (mCRPC), melanoma, pancreatic cancer, hepatocellular carcinoma (HCC), ov...
Phase 1
Pittsburgh, Pennsylvania, United States and 9 other locations
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