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to determine the safety and preliminary evidence of a therapeutic effect of azeliragon in patients refractory to prior treatment of metastatic pancreatic...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 5 other locations
and clinical activity of AB680 in combination with Zimberelimab (AB122), nab-paclitaxel and gemcitabine in participants with advanced pancreatic...
Phase 1
Pittsburgh, Pennsylvania, United States and 17 other locations
A Phase Ib/II, open-label, multicenter, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 26 other locations
The study is a multi-center, open-label, randomized active controlled study of subjects with locally advanced pancreatic adenocarcinoma whic...
Phase 3
Pittsburgh, Pennsylvania, United States and 40 other locations
This trial will study tisotumab vedotin to find out whether it is an effective treatment alone or with other anticancer drugs for certain solid tumors...
Phase 2
Pittsburgh, Pennsylvania, United States and 71 other locations
and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers...
Phase 2
Pittsburgh, Pennsylvania, United States and 65 other locations
This is a Phase 1/2, first-in-human, open-label, dose escalation and dose-expansion study of E-602, administered alone and in combination with cemipl...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 12 other locations
administered orally as monotherapy in patients with advanced solid tumors with gene alterations in the RAS- MAPK pathway for whom there are ...
Phase 1
Pittsburgh, Pennsylvania, United States and 4 other locations
of care. It is being tested against advanced and/or metastatic solid tumors including gastric, gastroesophageal junction, pancreatic...
Phase 1, Phase 2
Pittsburgh, Pennsylvania, United States and 17 other locations
This is a first in human (FIH) 2-part study using ACTM-838 in patients with advanced solid tumors resistant to standard of care treatment. P...
Phase 1
Pittsburgh, Pennsylvania, United States and 3 other locations
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