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Alliance for Multispecialty Research, LLC | AMR Knoxville, TN

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Top conditions

Top treatments

MK-0616
Cytisinicline
Orforglipron
Retatrutide
MDMA
LY3502970
CTP-543
Ruxolitinib
Ipilimumab
LY4100511

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Active trials

26 of 61 total trials

A Clinical Study Investigating the Safety and Immune Responses After Immunization With Investigational Monkeypox Vaccines

This is a dose-escalation, Phase I/II study evaluating the safety, tolerability, reactogenicity and immunogenicity of the investigational RNA-based m...

Active, not recruiting
Monkeypox
Biological: BNT166a

The purpose of this study is to evaluate the safety and reactogenicity of mRNA-1195 in healthy participants.

Enrolling
Epstein-Barr Virus Infection
Biological: Placebo
Biological: mRNA-1195.1

This is a multi-center, randomized, double-blind, placebo-controlled, parallel group dose-finding study to evaluate the efficacy and safety of CT-388...

Active, not recruiting
Overweight
Obesity
Drug: CT-388
Drug: Placebo

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabete...

Active, not recruiting
Chronic Kidney Disease
Overweight
Drug: Orforglipron
Drug: Insulin Glargine

The goal of this study is to evaluate the efficacy, safety, and tolerability of enlicitide decanoate in adult participants with hypercholesterolemia....

Active, not recruiting
Hypercholesterolemia
Familial Hypercholesterolemia
Drug: Enlicitide Decanoate
Drug: Placebo

The goal of the study is to learn about the safety of MK-2060 and if people tolerate it when MK-2060 is given in different forms.

Active, not recruiting
Venous Thrombosis
Biological: MK-2060
Biological: Placebo

This study will investigate the safety and efficacy of once daily oral treatment with orforglipron compared with placebo on body weight in adult part...

Active, not recruiting
Overweight
Obesity
Drug: Orforglipron
Drug: Placebo

This is a study of retatrutide in participants with obesity. The main purpose is to learn more about how retatrutide maintains body weight loss. The...

Enrolling
Obesity
Drug: Retatrutide
Drug: Placebo

Epstein Barr virus (EBV) is a virus which can cause infectious mononucleosis and is associated with certain kinds of cancer and multiple sclerosis. R...

Enrolling
Healthy
Biological: V350A
Biological: Placebo

The objectives of this first-in-human study is to evaluate the tolerability, safety, and immunogenicity of MVX01, a pneumococcal vaccine candidate, a...

Active, not recruiting
Pneumococcal Vaccine
Biological: MVX01
Biological: MVX01 Placebo

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who hav...

Enrolling
Atherosclerotic Cardiovascular Disease (ASCVD)
Elevated Lp(a)
Drug: Lepodisiran Sodium
Drug: Placebo

The purpose of this study is to learn about the safety and immune effects of a pneumococcal vaccine in adults. This vaccine can possibly provide prot...

Active, not recruiting
Pneumococcal Disease
Biological: 20-valent pneumococcal conjugate vaccine (20vPnC)
Biological: Licensed pneumococcal comparator vaccine

This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have ca...

Active, not recruiting
Obesity
Drug: Placebo
Drug: survodutide
Locations recently updated

Researchers are looking for new ways to prevent cancers related to human papillomavirus (HPV). HPV is a common virus that can cause an infection. The...

Enrolling
Healthy
Biological: GARDASIL®9
Biological: V540D

In this open-label Phase 3b, single arm trial, persistence of antibodies and long term safety will be evaluated in up to 375 participants rolled over...

Active, not recruiting
Chikungunya Virus Infection
Biological: VLA1553

The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smok...

Active, not recruiting
Tobacco Use
Other: Smoking Abstinence (menthol)
Other: Smoking Abstinence (non-menthol)

The main purpose of this study is to compare the bioavailability of 3 different formulations of LY4100511 and if the use of a proton pump inhibitor (...

Enrolling
Healthy Participants
Drug: Rabeprazole
Drug: LY4100511

This is a phase 3, randomized, placebo-controlled study of the efficacy and safety of enlicitide decanoate, an oral proprotein convertase subtilisin/...

Enrolling
Arteriosclerosis
Hypercholesterolaemia
Drug: Placebo
Drug: Enlicitide Decanoate

The goal of this clinical trial to learn how MDMA is processed in people with abnormal liver function.The main questions it aims to answer are:Do peo...

Begins enrollment in 11 months
Hepatic Impairment
Pharmacokinetics
Drug: Midomafetamine HCl

The main purpose of this study is to compare dose levels of petrelintide versus placebo with regards to effect on body weight, safety, and tolerabili...

Active, not recruiting
Obesity
Drug: Petrelintide
Drug: Placebo

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