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Active trials

12 of 41 total trials

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN) (ASPIRE-FTD)

The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called...

Enrolling
Dementia, Frontotemporal
Frontotemporal Dementia
Genetic: Intrathalamic AVB-101
Procedure: Intrathalamic AAV.PGRN administration

The purpose of this pre-market clinical study is to evaluate the performance (efficacy) and safety of an autonomous blood drawing device (Venipunctur...

Enrolling
Phlebotomy
Venipuncture
Device: Venipuncture Device (VD)

Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) is limited due to small patient populations. Patients with Behç...

Enrolling
Idiopathic Inflammatory Myopathies
IgG4-related Disease
Drug: Filgotinib

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome of excessive immune activation. ELA026 is a fully human IgG1 S...

Enrolling
Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Drug: ELA026

The goal of this diagnostic randomised clinical trial is to determine, in glioblastoma patients with diagnostic uncertainty between pseudoprogression...

Begins enrollment this month
Glioblastoma
Radionecrosis of Brain
Other: Clinical management based on the index MRI and an additional [¹⁸F] FET PET scan

This study is a multicenter, open-label, single-arm Phase 2 clinical trial. Approximately 15 female participants with clinically diagnosed postpartum...

Enrolling
Postpartum Depression
Postnatal Depression
Drug: GH001

A Phase 3, randomized, blinded study comparing pelabresib (CPI-0610) and ruxolitinib with placebo and ruxolitinib in myelofibrosis (MF) patients that...

Active, not recruiting
Myelofibrosis
Post-essential Thrombocythemia Myelofibrosis
Drug: Pelabresib
Drug: Placebo

The study is a global, multi-center safety and efficacy trial of epcoritamab, an antibody also known as EPKINLY™ and GEN3013 (DuoBody®-CD3xCD20). Epc...

Enrolling
Small Lymphocytic Lymphoma
Richter's Syndrome
Drug: Lenalidomide
Drug: Venetoclax

This study will randomize patients recently discharged from the hospital with a confirmed diagnosis of type 1 acute myocardial infarction (Thygesen e...

Invitation-only
Acute Myocardial Infarction
Combination Product: Placebo
Combination Product: Selatogrel

A Phase 1 first-in-human dose-escalation and dose-expansion study of BMF-219, an oral covalent menin inhibitor, in adult patients with AML, ALL (with...

Enrolling
Myelomatosis
Acute Mixed-Phenotype Leukemia
Drug: BMF-219

A research study looking at a new treatment for patients with advanced cancer, to investigate different doses of the experimental study drug, EP0042,...

Enrolling
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Drug: EP0042

Rationale:Sodium glucose co transporter 2 (SGLT2) inhibitors are a relatively new class of agents, originally developed as oral antihyperglycemic dru...

Invitation-only
Kidney Failure
Death
Drug: Dapagliflozin 10 mg/day (oral)
Drug: Placebo

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