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Active trials

34 of 221 total trials

[18F]ACI-19626 PET in TDP-43 Proteinopathies

The goal of this clinical trial is to test whether we can reliably and safely measure the accumulation of pathological protein TDP-43 \[involved in r...

Enrolling
Alzheimer's Disease (AD)
Suspected Limbic Predominant Age-related TDP-43 Encephalopathy (LATE)
Other: [18F]ACI-19626

This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the...

Enrolling
ST-elevation Myocardial Infarction (STEMI)
Drug: Placebo
Drug: zalunfiban

A pivotal, randomized, double-blind, placebo controlled, multi-center therapeutic study for patients age 4 and older with a confirmed diagnosis of Ni...

Active, not recruiting
Niemann-Pick Disease, Type C
Other: Placebo
Drug: N-Acetyl-L-Leucine

This is a Phase 1b study to evaluate different doses of the drug and see whether a drug is safe and how it behaves in the body.THN391 has already bee...

Not yet enrolling
Alzheimer Disease, Early Onset
Drug: THN391
Drug: Placebo

This is a Phase 1/2 randomized, blinded, dose-escalation study to evaluate the safety and efficacy of intrathecal (IT) administration of SBT101, a re...

Enrolling
X-ALD
AMN Gene Mutation
Genetic: SBT101
Procedure: Imitation Procedure

The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called...

Enrolling
Dementia, Frontotemporal
Frontotemporal Dementia
Genetic: Intrathalamic AVB-101
Procedure: Intrathalamic AAV.PGRN administration

The goal of this clinical trial is to learn if CIT-013 works to treat rheumatoid arthritis in adults. It will also learn about the safety of CIT-013....

Not yet enrolling
Rheumatoid Arthritis
Drug: CIT-013 low dose
Drug: CIT-013 high dose

An open-label, dose-escalation study to explore the safety, tolerability and pharmacokinetics of EP-104IAR in adults with eosinophilic esophagitis (E...

Enrolling
Eosinophilic Esophagitis
Drug: EP-104IAR

WiNK is a Phase I/IIa trial to evaluate the safety and efficacy of oNKord® in 33 adults with acute myeloid leukemia (AML) who are in morphologic comp...

Enrolling
Acute Myeloid Leukemia
Drug: Cyclophosphamide-Fludarabine (Cy/Flu)
Drug: oNKord®

To determine the safety and effectiveness of IMPEDE-FX RapidFill to increase the percentage of subjects with shrinkage of the abdominal aortic aneury...

Enrolling
Aortic Aneurysm, Abdominal
Procedure: EndoVascular Aneurysm Repair
Device: IMPEDE-FX RapidFill Implants

The purpose of this study is to learn more about the safety and efficacy of ivosidenib taken with azacitidine to treat adult patients with acute myel...

Enrolling
Acute Myeloid Leukemia (AML)
Drug: Ivosidenib 500mg Oral Tablet
Drug: Azacitidine

An open-label study for participants who received VRDN-001 or placebo and were non-responders at end of the treatment period assessment (i.e., 15 wee...

Active, not recruiting
Thyroid Eye Disease
Drug: Intervention/Treatment

The purpose of this pre-market clinical study is to evaluate the performance (efficacy) and safety of an autonomous blood drawing device (Venipunctur...

Enrolling
Phlebotomy
Venipuncture
Device: Venipuncture Device (VD)

Evaluate the efficacy and safety of the C2 CryoBalloon 180° Ablatie Systeem (CBAS180) at decremental doses for the treatment of dysplastic Barrett's...

Enrolling
Cryotherapy
Ablation Therapy
Device: C2 CryoBalloon 180° Ablation System

Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) is limited due to small patient populations. Patients with Behç...

Enrolling
Idiopathic Inflammatory Myopathies
IgG4-related Disease
Drug: Filgotinib

The goal of this diagnostic randomised clinical trial is to determine, in glioblastoma patients with diagnostic uncertainty between pseudoprogression...

Not yet enrolling
Glioblastoma
Radionecrosis of Brain
Other: Clinical management based on the index MRI and an additional [¹⁸F] FET PET scan

This is a multicenter, single arm, phase II study evaluating the efficacy of image-guided de-escalating neoadjuvant treatment with paclitaxel, Hercep...

Active, not recruiting
Breast Cancer
Drug: PTC-Pz

The ITHACA study is a phase I study evaluating the safety and toxicity of a peritumorally injected PD-1 checkpoint inhibitor, in combination with a m...

Not yet enrolling
Cervical Cancer
Drug: Anti-PD-1 antibody balstilimab

Recently, a new device for measuring physiological lesion severity, the pressure microcatheter, was introduced. The pressure microcatheter provides s...

Enrolling
Coronary Artery Disease
Acute Coronary Syndrome
Procedure: Pressure Microcatheter guided strategy - Standard of care
Procedure: Pressure Microcatheter guided strategy - PIOS MC

This is a long-term follow-up study for participants treated with Galapagos (GLPG) CAR T-cell therapies to evaluate the long-term safety and efficacy...

Enrolling
Hematological Malignancies
Genetic: GLPG CAR T-cell therapy

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