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Active trials

27 of 190 total trials

A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE)

This is a Phase 3 prospective, blinded, randomized, placebo controlled, international multicenter study. Subjects with STEMI will be enrolled in the...

Enrolling
ST-elevation Myocardial Infarction (STEMI)
Drug: Placebo
Drug: zalunfiban

A pivotal, randomized, double-blind, placebo controlled, multi-center therapeutic study for patients age 4 and older with a confirmed diagnosis of Ni...

Active, not recruiting
Niemann-Pick Disease, Type C
Other: Placebo
Drug: N-Acetyl-L-Leucine

This Phase 3 study is designed to compare the efficacy and safety of mirvetuximab soravtansine (MIRV) vs. IC chemotherapy in participants with platin...

Active, not recruiting
Epithelial Ovarian Cancer
Peritoneal Cancer
Drug: Paclitaxel
Drug: Pegylated liposomal doxorubicin

This is a Phase 1/2 randomized, blinded, dose-escalation study to evaluate the safety and efficacy of intrathecal (IT) administration of SBT101, a re...

Enrolling
X-ALD
AMN Gene Mutation
Genetic: SBT101
Procedure: Imitation Procedure

The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called...

Enrolling
Dementia, Frontotemporal
Frontotemporal Dementia
Genetic: Intrathalamic AVB-101
Procedure: Intrathalamic AAV.PGRN administration

The goal of this clinical trial is to learn if CIT-013 works to treat rheumatoid arthritis in adults. It will also learn about the safety of CIT-013....

Begins enrollment this month
Rheumatoid Arthritis
Drug: CIT-013 low dose
Drug: CIT-013 high dose

An open-label, dose-escalation study to explore the safety, tolerability and pharmacokinetics of EP-104IAR in adults with eosinophilic esophagitis (E...

Enrolling
Eosinophilic Esophagitis
Drug: EP-104IAR

WiNK is a Phase I/IIa trial to evaluate the safety and efficacy of oNKord® in 33 adults with acute myeloid leukemia (AML) who are in morphologic comp...

Enrolling
Acute Myeloid Leukemia
Drug: Cyclophosphamide-Fludarabine (Cy/Flu)
Drug: oNKord®

The purpose of this study is to learn more about the safety and efficacy of ivosidenib taken with azacitidine to treat adult patients with acute myel...

Enrolling
Acute Myeloid Leukemia (AML)
Drug: Ivosidenib 500mg Oral Tablet
Drug: Azacitidine

The purpose of this pre-market clinical study is to evaluate the performance (efficacy) and safety of an autonomous blood drawing device (Venipunctur...

Enrolling
Phlebotomy
Venipuncture
Device: Venipuncture Device (VD)

Evaluate the efficacy and safety of the C2 CryoBalloon 180° Ablatie Systeem (CBAS180) at decremental doses for the treatment of dysplastic Barrett's...

Enrolling
Cryotherapy
Ablation Therapy
Device: C2 CryoBalloon 180° Ablation System

Research into novel therapies for rare, immune-mediated inflammatory diseases (IMIDs) is limited due to small patient populations. Patients with Behç...

Enrolling
Idiopathic Inflammatory Myopathies
IgG4-related Disease
Drug: Filgotinib

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome of excessive immune activation. ELA026 is a fully human IgG1 S...

Enrolling
Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Drug: ELA026

The goal of this diagnostic randomised clinical trial is to determine, in glioblastoma patients with diagnostic uncertainty between pseudoprogression...

Not yet enrolling
Glioblastoma
Radionecrosis of Brain
Other: Clinical management based on the index MRI and an additional [¹⁸F] FET PET scan

This is a multicenter, single arm, phase II study evaluating the efficacy of image-guided de-escalating neoadjuvant treatment with paclitaxel, Hercep...

Active, not recruiting
Breast Cancer
Drug: PTC-Pz

The ITHACA study is a phase I study evaluating the safety and toxicity of a peritumorally injected PD-1 checkpoint inhibitor, in combination with a m...

Not yet enrolling
Cervical Cancer
Drug: Anti-PD-1 antibody balstilimab

Radioligand therapy (RLT) using Lutetium-177 labelled PSMA is a promising new therapeutic approach to treat metastatic prostate cancer. This tumor-sp...

Enrolling
Prostate Cancer
Drug: 177Lu-PSMA-617

This study is a multicenter, open-label, single-arm Phase 2 clinical trial. Approximately 15 female participants with clinically diagnosed postpartum...

Enrolling
Postpartum Depression
Postnatal Depression
Drug: GH001

A Phase 3, randomized, blinded study comparing pelabresib (CPI-0610) and ruxolitinib with placebo and ruxolitinib in myelofibrosis (MF) patients that...

Active, not recruiting
Myelofibrosis
Post-essential Thrombocythemia Myelofibrosis
Drug: Placebo
Drug: Pelabresib

The primary objective of this trial is to compare the safety and efficacy of the SINOMED BuMA Supreme biodegradable coronary stent in patients with u...

Active, not recruiting
Coronary Artery Disease
Device: Xience or Promus DES
Device: BuMA Supreme DES

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