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Active trials

18 of 173 total trials

A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy (REGAiN-1B)

To evaluate the durability of efficacy and long-term safety of intramuscular (IM) administration of Engensis or Placebo that was administered in the...

Enrolling
Diabetic Peripheral Neuropathy
Other: Placebo
Biological: Engensis

This is a longitudinal follow-up study of the RC-002 study, in which up to 246 subjects assigned to two randomization arms will be enrolled: an adipo...

Invitation-only
Partial Thickness Rotator Cuff Tear
Device: Adipose Derived Regenerative Cells
Device: Corticosteroid

The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-s...

Enrolling
Chronic Low-back Pain
Diabetic Neuropathic Pain
Drug: LY3016859 ISA
Drug: Placebo Oral

This is a 2-part, randomized, placebo-controlled, double-blind, Phase 2 study to evaluate the safety, tolerability, efficacy, and pharmacokinetics (P...

Enrolling
Diabetic Peripheral Neuropathic Pain
Drug: RTA 901
Drug: RTA 901-Matching Placebo

The purpose of this study was to assess efficacy, including inhibition of radiographic progression, and safety with upadacitinib versus placebo and v...

Active, not recruiting
Rheumatoid Arthritis
Drug: Placebo for Upadacitinib
Drug: Upadacitinib

The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master pr...

Active, not recruiting
Overweight
Knee Pain Chronic
Drug: Retatrutide
Drug: Placebo

The main purpose of this study is to evaluate the safety and efficacy of retatrutide once-weekly in participants who have obesity or are overweight a...

Active, not recruiting
Overweight
Obesity
Drug: Retatrutide
Drug: Placebo

The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate...

Active, not recruiting
Atopic Dermatitis
Drug: Upadacitinib
Drug: Placebo for Upadacitinib

The objective of this study is to assess the efficacy and safety of upadacitinib combined with topical corticosteroids (TCS) for the treatment of ado...

Invitation-only
Atopic Dermatitis
Drug: Placebo
Drug: Upadacitinib

The purpose of this investigation is to evaluate the safety and superior effectiveness in functional improvement in patients with partial-thickness r...

Active, not recruiting
Rotator Cuff Tear
Rotator Cuff Tendinitis
Device: Adipose Derived Regenerative Cells
Drug: Corticosteroid

Subjects receive study drug during bunionectomy and are followed for pain and opioid use, with the hypothesis that those who receive CPL-01 will have...

Enrolling
Bunion
Drug: Placebo
Drug: Local anesthetic injection of CPL-01

The purpose of the study is to evaluate the efficacy and safety of VX-548 in treating participants with PLSR.

Active, not recruiting
Painful Lumbosacral Radiculopathy
Drug: VX-548
Drug: Placebo

Subjects receive either CPL-01, positive control, or negative control after herniorrhaphy and are then followed.

Enrolling
Hernia, Inguinal
Drug: local anaesthetic injection

The main purpose of this study is to characterize the long-term safety and efficacy of the drug Deucravacitinib (BMS-986165) in patients who have bee...

Active, not recruiting
Psoriasis
Drug: BMS-986165

MR-107A-02 is being studied to investigate its efficacy and safety for treatment of acute pain after bunionectomy.

Active, not recruiting
Acute Pain
Pain
Drug: Placebo
Drug: Tramadol

The purpose of this study is to evaluate the efficacy and safety of intramuscular (IM) administration of Engensis on pain in participants with painfu...

Active, not recruiting
Diabetic Neuropathy, Painful
Biological: Engensis
Other: Placebo

This two-part study will be conducted in male and female patients, 30 - 80 years of age with painful OA of the index knee with Kellgren-Lawrence (K-L...

Active, not recruiting
Osteoarthritis, Knee
Biological: FX201

This study will evaluate the safety, efficacy, and PK of low dose (750 mg) and high-dose (1250 mg) XG005 oral tablets compared with placebo in subjec...

Enrolling
Acute Pain
Drug: XG005 tablet
Drug: Placebo tablet

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