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Ascension | St. Clair Nephrology Research

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VX-147
Lesinurad
BI 764198
RGLS8429
RGLS4326
Cyclosporine
CXA-10
Tacrolimus

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Active trials

3 of 9 total trials

Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease (AMPLITUDE)

The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants...

Enrolling
Proteinuric Kidney Disease
Drug: Placebo
Drug: VX-147

The purpose of this study is to assess the safety and efficacy (including durability) of up to 2 REACT injections given 3 months (+30 days) apart and...

Enrolling
Chronic Kidney Diseases
Type 2 Diabetes Mellitus
Biological: Renal Autologous Cell Therapy (REACT)
Procedure: Sham Comparator

This is a phase 3 study to evaluate effects on proteinuria and glomerular filtration rate of sibeprenlimab 400 mg subcutaneously (s.c.) Q 4 weeks in...

Active, not recruiting
Immunoglobulin A Nephropathy
Drug: Sibeprenlimab 400 mg
Drug: Placebo

Trial sponsors

R
Boehringer Ingelheim logo
Bristol-Myers Squibb (BMS) logo
C
Ironwood Pharmaceuticals logo
Otsuka logo
P
Vertex Pharmaceuticals logo

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