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Orion Clinical Research | Austin, TX

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Upadacitinib
Dupilumab
SAR443765
Lunsekimig
Remibrutinib
Rilzabrutinib
OPN-375
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Active trials

9 of 19 total trials
Locations recently updated

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab (Switch-Up)

Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not...

Enrolling
Atopic Dermatitis
Drug: Upadacitinib 30mg Dose
Drug: Upadacitinib 15mg Dose

This is a US, multi-center, randomized, double-blind, double-dummy, Phase 3b study to evaluate efficacy of remibrutinib (25 mg twice daily \[b.i.d.\]...

Enrolling
Chronic Spontaneous Urticaria (CSU)
Drug: Placebo solution for injection
Drug: Dupilumab

Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. The purpose of this study is to evaluat...

Enrolling
Atopic Dermatitis
Drug: Placebo
Drug: Lutikizumab

The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2...

Active, not recruiting
COVID-19
SARS-CoV2
Biological: VXA-CoV2-3.1
Biological: VXA-CoV2-3.3

The purpose of this extension study is to collect long-term efficacy, safety and tolerability data on remibrutinib in a selected group of participant...

Active, not recruiting
Chronic Spontaneous Urticaria
Drug: LOU064 (blinded)
Drug: Placebo

This is a Phase 2b, global, multicenter, randomized, double-blind, placebo-controlled, parallel group, dose ranging study to assess the efficacy, saf...

Active, not recruiting
Asthma
Drug: Placebo
Drug: Lunsekimig
Recently updated

This is a 12-Week randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluating the efficacy and safety of intranasal ad...

Enrolling
Chronic Rhinosinusitis Without Nasal Polyps
Drug: OPN-375
Drug: Placebo
Locations recently updated

This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with asthma who have...

Enrolling
Asthma
Drug: Lunsekimig

This is a parallel-group, Phase 2, randomized, double-blind, placebo-controlled, 2-arm study for the treatment of asthma.The purpose of this study is...

Enrolling
Asthma
Drug: Short-Acting Beta Agonists (SABA)
Drug: Fluticasone/salmeterol

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