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Orion Clinical Research | Austin, TX

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Upadacitinib
Dupilumab
SAR443765
Lunsekimig
Remibrutinib
Verekitug
Ritlecitinib
ABBV-157
Lutikizumab
Cedirogant

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Active trials

10 of 23 total trials
Status recently updated

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab (Switch-Up)

Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not...

Enrolling
Active, not recruiting
Atopic Dermatitis
Drug: Upadacitinib 30mg Dose
Drug: Upadacitinib 15mg Dose

This is a US, multi-center, randomized, double-blind, double-dummy, Phase 3b study to evaluate efficacy of remibrutinib (25 mg twice daily \[b.i.d.\]...

Active, not recruiting
Chronic Spontaneous Urticaria (CSU)
Drug: Placebo solution for injection
Drug: Dupilumab

Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. The purpose of this study is to evaluat...

Active, not recruiting
Atopic Dermatitis
Drug: Placebo
Drug: Lutikizumab

The primary objective of the study is to determine the relative efficacy of the investigational oral severe acute respiratory syndrome coronavirus 2...

Active, not recruiting
COVID-19
SARS-CoV2
Biological: VXA-CoV2-3.1
Biological: VXA-CoV2-3.3

The purpose of the study is to learn about the safety and effects of the study medicine (called ritlecitinib) for the treatment of chronic spontaneou...

Enrolling
Chronic Spontaneous Urticaria
Drug: Placebo - 100 mg
Drug: Ritlecitinib 50 mg

The purpose of this clinical study is to learn about the safety and effects of the study medicine (called tilrekimig) for the potential treatment of...

Enrolling
Asthma
Other: Placebo
Drug: tilrekimig

The purpose of this extension study is to collect long-term efficacy, safety and tolerability data on remibrutinib in a selected group of participant...

Active, not recruiting
Chronic Spontaneous Urticaria
Drug: LOU064 (blinded)
Drug: Placebo

This is a 12-Week randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluating the efficacy and safety of intranasal ad...

Enrolling
Chronic Rhinosinusitis Without Nasal Polyps
Drug: OPN-375
Drug: Placebo

This is a phase 2, open-label extension study to evaluate the long-term safety and efficacy of lunsekimig in adult participants with asthma who have...

Invitation-only
Asthma
Drug: Lunsekimig

This is a parallel-group, Phase 2, randomized, double-blind, placebo-controlled, 2-arm study for the treatment of asthma.The purpose of this study is...

Active, not recruiting
Asthma
Drug: Budesonide/Albuterol
Drug: Lunsekimig

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