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Boca Raton Regional Hospital | Lynn Clinical Research Center

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Active trials

16 of 86 total trials

A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1)

This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and earl...

Enrolling
Solid Tumor
Pleural Mesothelioma
Drug: Pembrolizumab
Drug: MDNA11

This is a multi-center clinical study enrolling up to 86 participants. The primary objectives are to determine the objective response rate (ORR) esta...

Enrolling
Recurrent Squamous Cell Carcinoma
Device: DaRT seeds

The main purpose of this study is to evaluate how safe and effective the study drug known as abemaciclib is in participants with lung cancer.

Active, not recruiting
Non Small Cell Lung Cancer
Drug: Erlotinib
Drug: Abemaciclib

The purpose of this study is to evaluate whether milvexian compared to placebo reduce the risk of recurrent ischemic stroke.

Enrolling
Ischemic Stroke; Ischemic Attack, Transient
Drug: Placebo
Drug: Milvexian

The purpose of study is to compare bladder intact-event free survival (BI-EFS) in participants receiving TAR-200 in combination with intravenous (IV)...

Enrolling
Urinary Bladder Neoplasms
Drug: Cisplatin
Radiation: Hypo-fractioned radiation therapy

The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetax...

Enrolling
Prostate Cancer
Drug: Radium-223
Drug: Docetaxel 60 mg/m2

This is a Phase 2b, randomized, open label study to assess the safety and efficacy of DPX-Survivac and pembrolizumab, with and without low-dose cyclo...

Enrolling
Refractory Diffuse Large B-cell Lymphoma
Relapsed Diffuse Large B-cell Lymphoma
Drug: DPX-Survivac
Drug: Pembrolizumab

The goal of this clinical trial is to assess the efficacy, safety and tolerability of the combination of lasofoxifene and abemaciclib compared to ful...

Enrolling
Metastatic Breast Cancer
Drug: Lasofoxifene in combination with abemaciclib
Drug: Fulvestrant in combination with abemaciclib

This phase II trial studies how well genetic testing works in guiding treatment for patients with solid tumors that have spread to the brain. Several...

Enrolling
KRAS G12C Mutation
PI3K Gene Mutation
Drug: Entrectinib
Drug: PI3K Inhibitor paxalisib

The purpose of this study is to determine the long-term performance of the TREO Abdominal Stent-Graft as a treatment for patients with Infrarenal Abd...

Enrolling
Abdominal Aortic Aneurysm
Device: TREO Abdominal Stent-Graft System

This is a study of the efficacy, pharmacokinetics, and safety of DS-1062a in participants with advanced or metastatic non-small cell lung cancer (NSC...

Active, not recruiting
Non-small Cell Lung Cancer
Drug: DS-1062a

This is a study for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia (SLL) who have previously received treatment with...

Active, not recruiting
Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia
Drug: Idelalisib
Drug: Bendamustine

Follicular Lymphoma (FL) is the second most common B-cell cancer and the most common type of cancer of lymphocytes. Unfortunately, this disease is in...

Enrolling
Follicular Lymphoma (FL)
Drug: Lenalidomide
Drug: Epcoritamab

The aim of this study is to provide darolutamide treatment to patients who participated in a previous study with darolutamide supported by Bayer and...

Enrolling
Cancer
Drug: Darolutamide (Nubeqa, BAY1841788)

This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in pa...

Enrolling
Prognostic Stage IA Breast Cancer AJCC v8
Prognostic Stage IB Breast Cancer AJCC v8
Other: Questionnaire Administration
Other: Quality-of-Life Assessment

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with me...

Enrolling
Recurrent Meningioma
NF2 Gene Mutation
Drug: Abemaciclib
Drug: Vismodegib

Trial sponsors

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Memorial Sloan Kettering Cancer Center (MSK) logo
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