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Active trials

26 of 37 total trials

A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS G12C mutation to determine the maximum tolerated dose and recom...

Solid Tumor
Cancer of Pancreas
Drug: HBI-2438

A Phase 1 dose escalation study in patients with advanced solid tumors harboring KRAS or EGFR mutations to determine the maximum tolerated dose and r...

Solid Tumor
Cancer of Colon
Drug: HBI-2376

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced sol...

HER2-positive Advanced Solid Tumor
Drug: Itraconazole
Drug: Ritonavir

The study is designed to evaluate the safety and efficacy of rusfertide in subjects with polycythemia vera (PV) in maintaining hematocrit control and...

Polycythemia Vera
Drug: Placebo
Drug: Rusfertide

This is a Phase 3 double-blind, placebo-controlled, randomized study designed to investigate whether tafasitamab and lenalidomide as an add-on to rit...

Active, not recruiting
Marginal Zone Lymphoma
Follicular Lymphoma
Drug: rituximab
Drug: placebo

The purpose of the study is to evaluate the overall survival of participants treated with imetelstat compared to best available therapy with intermed...

Drug: Imetelstat
Drug: Best Available Therapy (BAT)

This is a Phase 2/3 study that comprises 5 substudies designed to evaluate the efficacy, safety, and tolerability of oral etrasimod as therapy in adu...

Crohn's Disease
Drug: Placebo
Drug: Etrasimod

The purpose of this study is to evaluate two study medicines (encorafenib plus cetuximab) taken alone or together with standard chemotherapy for the...

Active, not recruiting
Drug: Cetuximab
Drug: Oxaliplatin

The participants of this study would have relapsed/refractory follicular lymphoma.Follicular lymphoma is a type of blood cancer. It is referred to as...

Relapsed/Refractory Follicular Lymphoma
Follicular Lymphoma
Combination Product: Rituximab
Drug: Placebo oral tablet

The purpose of this study is to compare the efficacy and safety of fixed duration pirtobruitinib (LOXO-305) with VR (Arm A) compared to VR alone (Arm...

Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia
Drug: Venetoclax
Drug: Rituximab

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative ne...

Other: Placebo
Drug: ACE-536

The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of TTFields, using the NovoTTF-200T device, c...

Active, not recruiting
Nonsmall Cell Lung Cancer
Drug: Immune checkpoint inhibitors or docetaxel
Device: NovoTTF-200T

Brief Summary:The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFie...

Active, not recruiting
Pancreas Adenocarcinoma
Drug: Gemcitabine
Drug: nab paclitaxel

The goal of this clinical trial is to test ELVN-002 in people with cancers that have an abnormal HER2 gene. The main question the trial aims to answe...

HER2 Mutant Non-small Cell Lung Cancer
HER2 Amplification
Drug: ELVN-002
Drug: Trastuzumab emtansine

The purpose of this study is to determine the safety, tolerability, and recommended dose of ELVN-002 in combination with trastuzumab in participants...

HER2 Positive Solid Tumors
HER2-positive Gastric Cancer
Drug: paclitaxel
Drug: Leucovorin

A Phase 1/2a Open-Label Dose Escalation and Dose Expansion Study of T3011 when Administered Intravenously as a Single Agent and in Combination with O...

Active, not recruiting
Endometrial Cancer
Solid Tumor
Biological: T3011

This is a multicenter, open-label, single-arm Phase II study to evaluate anti-tumor efficacy and safety of NT-I7 in combination with atezolizumab in...

Active, not recruiting
Non-Small Cell Lung Carcinoma
Nonsmall Cell Lung Cancer
Drug: efineptakin alfa
Drug: Atezolizumab

The purpose of this study is to compare the effect of Eflapegrastim on duration of neutropenia in patients with early-stage breast cancer when admini...

Active, not recruiting
Breast Cancer
Biological: Eflapegrastim
Drug: Cyclophosphamide

Multicenter, open-label study of various ASTX727 LD doses and schedules to assess safety, pharmacodynamics, pharmacokinetics, and hematologic respons...

Active, not recruiting
Myelodysplastic Syndromes
Drug: ASTX727 LD
Drug: ASTX727 SD

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with adva...

Metastatic Cancer
Advanced Cancer
Drug: Cetuximab
Drug: Afatinib

Trial sponsors

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