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Data sourced from clinicaltrials.gov

Active trials

6 of 145 total trials

A Food-Effect, Drug-Drug Interaction, and Pharmacokinetics Study of NX-5948 in Healthy Adult Subjects

This is a Phase 1, 2-part double-blinded (with respect to NX-5948/placebo), placebo-controlled study. Part 1 is a randomized, 3 period cross-over foo...

Active, not recruiting
Healthy Volunteers
Drug: Matching Placebo
Drug: IP

This is a Phase 1, 2-period, open-label, single-dose, fixed-sequence study to assess the absolute bioavailability, absorption, metabolism, excretion,...

Enrolling
Healthy Volunteer
Drug: NX-5948

The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smok...

Active, not recruiting
Tobacco Use
Other: Smoking Abstinence (menthol)
Other: Smoking Abstinence (non-menthol)

The principal aim of this study is to obtain safety and tolerability data when MRT-6160 is administered orally as single and multiple doses to health...

Enrolling
Healthy Volunteers
Drug: Placebo
Drug: MRT-6160

This is a first-in-human study to evaluate safety, pharmacokinetics, and pharmacodynamics of single and multiple dose levels of KT-621 in healthy mal...

Enrolling
Healthy Participants Study
Drug: Placebo
Drug: KT-621

This is a 2-cohort, fixed-sequence, 3-period, relative bioavailability, food-effect, and drug-drug interaction study. It is an open-label study evalu...

Enrolling
Healthy Volunteer
Drug: Esomeprazole
Drug: NX-5948 tablet

Trial sponsors

Merck Sharp & Dohme (MSD) logo
Takeda logo
Theravance Biopharma logo
Janssen (J&J Innovative Medicine) logo
Bridge Biotherapeutics logo
G
M
N
R
Syndax Pharmaceuticals logo

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