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Active trials

7 of 161 total trials

A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years

Characterize the safety, tolerability and pharmacokinetics of ORX489 following single and multiple doses.

Enrolling
Healthy Adult Male and Female Volunteers
Drug: ORX489 Tablets
Other: Placebo Tablets

This study will be conducted to evaluate the effect of food on the single-dose pharmacokinetics and a drug-drug interaction evaluation of itraconazol...

Enrolling
Healthy Participants
Drug: itraconazole
Drug: rifampin

This is a first-in-human study to evaluate safety and tolerability, pharmacokinetics, and pharmacodynamics of single and multiple dose levels of KT-5...

Enrolling
Healthy Participants
Drug: KT-579
Drug: Placebo

The purpose of the study is to investigate the routes of elimination and overall mass balance of 100 mg quemliclustat containing 75 μCi \[14C\] follo...

Enrolling
Healthy Participants
Drug: Quemliclustat

This first-in-human study is a randomized, double-blind, placebo-controlled, single-ascending dose and multiple-ascending dose study of SL-325 in hea...

Enrolling
Healthy Volunteers
Biological: SL-325
Other: Placebo (Normal Saline)

This is a multiple part, multiple cohort study evaluating the relative bioavailability, food effect, and drug-drug interaction of NX-5948 in healthy...

Enrolling
Healthy Volunteer
Drug: Esomeprazole
Drug: NX-5948

A Single-center, Open-label, Single-dose, Three-period, Fixed Sequence Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 204...

Enrolling
Alzheimer Disease
Epilepsy
Drug: NPT 2042 (Test formula/Formulation 2)
Drug: NPT 2042 (Reference formula/Formulation 1)

Trial sponsors

Merck Sharp & Dohme (MSD) logo
Takeda logo
Theravance Biopharma logo
Incyte logo
Janssen (J&J Innovative Medicine) logo
Arcus Biosciences logo
Bridge Biotherapeutics logo
Edgewise Therapeutics logo
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