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Charité Universitätsmedizin Berlin | Institute of Allergology (IFA) - Campus Benjamin Franklin logo

Charité Universitätsmedizin Berlin | Institute of Allergology (IFA) - Campus Benjamin Franklin

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Top conditions

Top treatments

Remibrutinib
Deucrictibant
Briquilimab
STAR-0215
Dupilumab
CDX-0159
Omalizumab
Rocatinlimab
BLU-263
PHA-022121

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Active trials

27 of 29 total trials

(HARBOR) Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

This is a randomized, double-blind, placebo-controlled, Phase 2/3 study comparing the efficacy and safety of elenestinib (BLU-263) + best supportive...

Enrolling
Monoclonal Mast Cell Activation Syndrome
Smoldering Systemic Mastocytosis
Drug: Placebo
Drug: Elenestinib

This is a multi-part, randomized, double-blind, placebo-controlled Phase 2 clinical study comparing the safety and efficacy of bezuclastinib (CGT9486...

Active, not recruiting
ISM
Mastocytosis
Drug: Bezuclastinib Tablets (Formulation A)
Drug: Placebo Tablets

The purpose of this trial is:1. to assess the efficacy, pharmacokinetics, and safety of remibrutinib vs. placebo in adolescents from 12 to \< 18 year...

Enrolling
Chronic Spontaneous Urticaria
Drug: placebo
Drug: LOU064 (blinded)
Locations recently updated

The goal of this trial is to enable the collection of information about long-term safety and clinical activity of STAR-0215 in participants with here...

Enrolling
Hereditary Angioedema
Drug: STAR-0215

The purpose of this study is to assess the clinical effect, the pharmacodynamics, the safety, and the pharmacokinetics of barzolvolimab (CDX-0159) in...

Active, not recruiting
Chronic Spontaneous Urticaria
Biological: barzolvolimab
Drug: Matching Placebo

Phase 2, open-label, extension study to evaluate the long-term safety, clinical activity, and pharmacodynamics of briquilimab in participants previou...

Invitation-only
Urticaria Chronic
Drug: Briquilimab

The main objective of the study will be to evaluate the efficacy of rocatinlimab compared with placebo at week 24 on the patient-reported outcome (PR...

Enrolling
Prurigo Nodularis
Drug: Placebo
Drug: Rocatinlimab

The purpose of this study is to assess the efficacy and safety of barzolvolimab in adults with prurigo nodularis.

Enrolling
Prurigo Nodularis
Other: Matching Placebo
Biological: barzolvolimab

The purpose of this study is to assess the clinical effect, the pharmacodynamics, the safety, and the pharmacokinetics of barzolvolimab (CDX-0159) in...

Active, not recruiting
Chronic Inducible Urticaria
Drug: Matching Placebo
Biological: barzolvolimab

The goal of this clinical trial is to test the drug STAR-0215 in participants with hereditary angioedema (HAE). One group of participants will get 1...

Active, not recruiting
Hereditary Angioedema
Drug: STAR-0215
Locations recently updated

The purpose of this study is to evaluate effect of povorcitinib on itch and skin lesions in participants with prurigo nodularis.

Enrolling
Prurigo Nodularis
Drug: Povorcitinib
Drug: Placebo

This is a Phase 3, parallel group, placebo-controlled, double-blind, confirmatory study in patients with CINDU, with an optional Open-label Extension...

Enrolling
Chronic Inducible Urticaria
Drug: Remibrutinib
Other: Placebo
Locations recently updated

This is a parallel, Phase 3, 2-arm study for treatment. The purpose of this study is to measure improvement in pruritus with dupilumab subcutaneous i...

Enrolling
Lichen Simplex Chronicus
Drug: Placebo
Drug: Dupilumab

The purpose of this extension study is to collect long-term efficacy, safety and tolerability data on remibrutinib in a selected group of participant...

Active, not recruiting
Chronic Spontaneous Urticaria
Drug: LOU064 (blinded)
Drug: Placebo

The purpose of this study is to investigate the safety, PK / PD, and efficacy of SC CSL312 for prophylactic treatment of pediatric subjects with HAE.

Active, not recruiting
Hereditary Angioedema (HAE)
Biological: CSL312

This trial will be performed as a three-part dose escalating clinical trial where Parts 1 is open label and Parts 2 and 3 are randomized, double-blin...

Enrolling
Chronic Spontaneous Urticaria
Drug: Briquilimab
Other: Placebo

The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO.This is a master protocol whic...

Enrolling
Pruritus
Drug: Placebo
Drug: Dupilumab

The study duration for an individual subject includes screening (14 days), the treatment period (28 days) and the observational follow-up period of 2...

Enrolling
Hidradenitis
Chronic Urticaria, Idiopathic
Drug: CSU high dose treatment
Drug: CSU lower dose treatment

This study evaluates the safety and efficacy of long-term on-demand treatment with orally administered deucrictibant for acute hereditary angioedema...

Invitation-only
Hereditary Angioedema - Type 2
Hereditary Angioedema Types I and II
Drug: deucrictibant selected dose

This Phase 3 study aims to evaluate the efficacy and safety of NTLA-2002 compared to placebo in adult participants with HAE.

Enrolling
Hereditary Angioedema
Biological: Normal Saline IV Administration
Biological: NTLA-2002

Trial sponsors

Novartis logo
P
Celldex Therapeutics logo
A
E
J
Sanofi logo
Amgen logo
B
CSL Behring logo

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