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Active trials

24 of 95 total trials

4-Week, Multi-center Dose-Ranging Study for the IBS-C in Pts. 6 to <12 Yrs

This is a randomized, double-blind, placebo-controlled dose-ranging study to assess the safety and efficacy of tenapanor for treatment of the IBS-C i...

Enrolling
Irritable Bowel Syndrome With Constipation (IBS-C)
Drug: Tenapanor
Drug: Placebo

The objective of the study is to evaluate the safety, tolerability, and immunogenicity of 4 injections of VAX-31 (at 4 dose levels) compared to PCV20...

Active, not recruiting
Pneumococcal Vaccines
Biological: 0.5 mL of the mid dose VAX-31
Biological: 0.5 mL of the High-PFS dose VAX-31

This is a Phase 3, randomized, double-blind study to evaluate the safety and immunogenicity of VAX-31 and seasonal influenza vaccine in pneumococcal-...

Enrolling
Pneumococcal Vaccines
Biological: 31-valent pneumococcal conjugate vaccine
Biological: Placebo

The reason for this study is to determine the long-term efficacy and safety of the study drug mirikizumab in participants with Crohn's disease.

Active, not recruiting
Crohn's Disease
Drug: Mirikizumab

This is a Phase 2a/b, randomized, double-blind, placebo-controlled, parallel-group, 6-arm study to evaluate the efficacy and safety of amlitelimab in...

Enrolling
Coeliac Disease
Celiac Disease
Dietary Supplement: SIGE
Drug: Placebo

The purpose of this trial is to assess the safety and relative efficacy of CVXGA (CVXGA50), a KP.2 containing vaccine, compared to COMIRNATY® (COVID-...

Active, not recruiting
COVID-19
Biological: CVXGA (CVXGA50)
Biological: COMIRNATY®
Locations recently updated

This study aims to check how safe and well-tolerated a second dose of RSVpreF is when given during later pregnancies, and to see how long the immunit...

Enrolling
RSV Infection
Biological: Placebo
Biological: RSVpreF

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with ob...

Enrolling
Overweight
Obesity
Drug: Macupatide
Drug: Macupatide Placebo
Locations recently updated

The main purpose of this study is to investigate the antiviral effect of S-337395 compared with placebo among nonhospitalized adult participants with...

Enrolling
Respiratory Syncytial Virus Infections
Drug: Placebo
Drug: S-337395

The purpose of this study is to evaluate the efficacy and safety of mRNA-1283 and mRNA-1273 (variant formulations) in adults 50 to 64 years of age wi...

Enrolling
SARS-CoV-2
Biological: mRNA-1283
Biological: mRNA-1273

The purpose of this study is to evaluate how well CD388 works in preventing symptomatic laboratory-confirmed influenza infections, as compared to pla...

Active, not recruiting
Influenza
Combination Product: CD388 Injection
Combination Product: Placebo

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prev...

Enrolling
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo

The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing th...

Enrolling
Clostridioides Difficile Associated Disease
Biological: C.difficile vaccine
Other: Saline Placebo

This study is designed to find out how well the COVID-19 vaccine protects people 50 to 64, who don't have any serious health problems, compared to a...

Enrolling
COVID-19
SARS-COV-2 Infection
Biological: Placebo
Biological: BNT162b2 Vaccine

The purpose of this study is to learn about the safety, tolerability, and immunogenicity of an updated vaccine against COVID-19, called BNT162b2 (202...

Enrolling
COVID-19
SARS-COV-2 Infection
Biological: BNT162b2 (2025/2026 formulation)

The purpose of this study is to learn about the safety and effects of the Lyme disease vaccine (called VLA15) when given at different time points.Thi...

Enrolling
Lyme Borreliosis
Biological: VLA15
Biological: Placebo

This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate...

Enrolling
Crohn's Disease
Drug: Duvakitug
Drug: Placebo

This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study to evaluate the efficacy and safety of du...

Enrolling
Ulcerative Colitis
Drug: Placebo
Drug: Duvakitug
Locations recently updated

BEATRIX (group B strEptococcus mATeRnal and Infant VaX study) The purpose of this study is to learn about the safety and how the group B streptococcu...

Enrolling
Healthy
Biological: Infanrix hexa
Biological: Prevnar 20

The purpose of this study is to evaluate the efficacy, immunogenicity and safety of the 9vHPV vaccine in men 20 to 45 years of age. The primary hypot...

Active, not recruiting
Papillomavirus Infections
Biological: 9vHPV Vaccine
Other: Placebo (Saline for Injection)

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