R&D Department

Clinique Ovo

Infertility

Male Infertility

Endometriosis

Spontaneous Abortion

Hot Flashes

Habitual Abortion

Myofibroma

Azoospermia

Hyperandrogenism

Polycystic Ovary Syndrome

Vilaprisan

Elinzanetant

Progesterone

Filgrastim

BAY1817080

Follitropin Delta

BAY3427080

Ovo Clinic

Bayer

Beckman Coulter

Lallemand

Dr François Bissonnette

condition

allSponsorName

Ferring

gender

Male

Female

overallStatus

Recruiting

Not yet recruiting

Active, not recruiting

Enrolling by invitation

Completed

Terminated

Withdrawn

Suspended

Unknown

type

Interventional

Observational

Expanded Access

phase

Early Phase 1

Phase 1

Phase 2

Phase 3

Phase 4

Not Applicable

funderTypes

Industry

Other U.S. Federal agency

All others

ageGroup

Child (birth-17)

Adult (18-64)

Older Adult (65+)

Endometrin is a progesterone supplement prescribed during in vitro fertilization (IVF) for preparation for embryo transfer. The usual dose of Endometrin is 100 mg two to three times per day in the form of an effervescent tablet to be inserted vaginally.

The purpose of this research project is to evaluate the dose response of the Endometrin when determined based on the blood level of progesterone on the day of the FET. According to the literature, a predefined level of progesterone in the blood should be reached in order to have favorable conditions for pregnancy. The hypothesis being that a woman with low progesterone levels would benefit from a dose of Endometrin of 600 mg (200 mg 3x/day) to decrease the risk of miscarriage and improve the chances of pregnancy. Women with adequate progesterone levels according to the literature, would continue with the standard dose of progesterone prescribed at clinique ovo which is 300 mg (100 mg 3x/day).

PIBF (Progesterone Induced Blocking Factor) levels, a protein found in the blood that could also predict pregnancy outcomes in women using IVF will also be looked at.

Rescue Progesterone Supplementation During Frozen Embryo Transfer

Clinique Ovo | R&D Department

Site insights

Work at this site?

Active trials

Rescue Progesterone Supplementation During Frozen Embryo Transfer (P4R)

Trial sponsors