Coastal Carolina Research Center | Mount Pleasant, SC

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BI 456906
Naltrexone Hydrochloride

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Active trials

35 of 79 total trials

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain (CPMP)

The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-s...

Chronic Low-back Pain
Diabetic Neuropathic Pain
Drug: LY3016859 ISA
Drug: Placebo Oral

a Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat (an aldosterone synthase inhibitor), administered on a background of a...

Drug: Placebo
Drug: lorundrostat Dose 2

This is a double-blind, saline-controlled, and randomized study with blinded assessments using a single dose. Subjects that have a current diagnosis...

Lumbar Disc Disease
Biological: BRTX-100
Drug: Saline

The main objective of Part A of this trial is to evaluate the safety and reactogenicity of mRNA-1189 in 18- to 30-year-old healthy adults and the mai...

Active, not recruiting
Epstein-Barr Virus Infection
Biological: mRNA-1189
Biological: Placebo

This Phase 1/2a trial is a randomized, placebo-controlled trial to evaluate the safety, tolerability and immunogenicity of two ascending doses (10\^6...

Respiratory Syncytial Virus Infections
Biological: PIV5-vectored RSV Vaccine (BLB-201) Low Dose
Biological: PIV5-vectored RSV Vaccine (BLB-201) High Dose

The goal of this study is to evaluate the efficacy, safety, and tolerability of MK-0616 in adult participants with hypercholesterolemia. The primary...

Active, not recruiting
Familial Hypercholesterolemia
Drug: MK-0616
Drug: Placebo

The purpose of this study is to evaluate the safety, reactogenicity, and relative vaccine efficacy (rVE) of the mRNA-1283.222 vaccine as well as its...

Active, not recruiting
Biological: mRNA-1273.222
Biological: mRNA-1283.222

This is a Phase 2B clinical study evaluating the effectiveness and safety of SP-624 as compared to placebo in the treatment of adults with Major Depr...

Major Depressive Disorder
Drug: SP-624
Drug: Placebo

The purpose of this study is to assess the safety, reactogenicity, and immunogenicity of 3 different doses of ExPEC10V and to select the optimal dose...

Active, not recruiting
Extraintestinal Pathogenic Escherichia Coli Prevention
Biological: ExPEC10V
Biological: ExPEC4V

This is a study of tirzepatide in participants with overweight and obesity. The main purpose is to learn more about how tirzepatide affects body weig...

Active, not recruiting
Drug: Placebo
Drug: Tirzepatide

The main purpose of this study is to evaluate the efficacy of mRNA 1647 vaccine in CMV-seronegative female participants and to evaluate the safety an...

Active, not recruiting
Cytomegalovirus Infection
Biological: mRNA-1647
Biological: Placebo

The purpose of this study is to understand the safety and effects of a combined influenza and COVID-19 vaccine. This combined vaccine is compared to...

Active, not recruiting
Biological: COVID-19 Vaccine
Biological: Investigational influenza vaccine

The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of different formulations of Quadriva...

Active, not recruiting
Influenza Immunization
Biological: Quadrivalent Influenza mRNA Vaccine MRT5429
Biological: Quadrivalent Influenza mRNA Vaccine MRT5421

The purpose of this study is to assess the change in 24-hour ambulatory blood pressure monitoring (ABPM) between baseline (Day 0) and Day 120 followi...

Drug: Natesto
Locations recently updated

This study is open to adults who are at least 18 years old and have a body mass index (BMI)bof 27 kg/m2 or more. People can take part if they have ca...

Drug: Placebo
Drug: survodutide

This is a Phase 3 multicenter, double-blind study to evaluate the safety and efficacy of vehicle-controlled topical MOB015B in the treatment of Dista...

Active, not recruiting
Drug: MOB015B
Drug: Vehicle (Placebo Comparator)

A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of single injection of...

Active, not recruiting
Drug: RTX-GRT7039
Drug: Placebo

A randomized, double-blinded, placebo controlled study intended to capture cardiovascular outcomes during real-world use of naltrexone/bupropion (NB).

Drug: Placebo
Drug: Naltrexone-Bupropion (NB) Combination
Locations recently updated

The purpose of this study is to determine the efficacy and safety of BHV-7000 in participants with Major Depressive Disorder (MDD)

Major Depressive Disorder
Drug: BHV-7000
Drug: Placebo

This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the...

Active, not recruiting
Knee Osteoarthritis
Biological: Amniotic Suspension Allograft
Drug: Placebo

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