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Active trials

11 of 13 total trials

A First-in-Human, Phase 1/2 Study of LAT010 in Patients with Advanced Solid Tumors (LIGHTSPEED-1)

This is an open-label, multicenter, Phase 1/2, first-in-human (FIH), dose-escalation and cohort-expansion study of LAT010 to evaluate the safety, tol...

Enrolling
Advanced Solid Tumor
Drug: LAT010
Drug: LAT010 + ICI

This is a Phase 1, open-label, first-in-human study of CTX-8371 administered as a monotherapy in patients with metastatic or locally advanced maligna...

Enrolling
Hodgkin Lymphoma
Malignant Melanoma
Drug: CTX-8371

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced sol...

Enrolling
HER2-positive Advanced Solid Tumor
Drug: Itraconazole
Drug: Ritonavir

The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or re...

Enrolling
Advanced MTAP-null Solid Tumors
Drug: Comparator AMG 193 Test Tablet
Drug: Docetaxel

The purpose of this study is to assess the safety, tolerability, and efficacy of CBX-12 in female subjects with platinum resistant or refractory ovar...

Enrolling
Refractory Ovarian Carcinoma
Platinum-resistant Ovarian Cancer
Drug: CBX-12

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1310 in subjects with advanced solid tumo...

Enrolling
Advanced Solid Tumor
Drug: Trastuzumab
Drug: DB-1310
Locations recently updated

The purpose of the study is to compare the efficacy and safety of Luspatercept vs epoetin alfa in the treatment of anemia in adults due to IPSS-R ver...

Enrolling
Myelodysplastic Syndromes
Biological: Epoetin Alfa
Biological: Luspatercept

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1305/BNT325 in subjects with advanced sol...

Enrolling
Advanced Solid Tumor
Combination Product: Pembrolizumab
Drug: BNT327

The goal of this Phase 3 clinical trial is study the safety and efficacy of the nextgen anti-CTLA-4 antibody, gotistobart (ONC-392/BNT316), in patien...

Enrolling
Non Small Cell Lung Cancer
Drug: Gotistobart
Drug: Docetaxel
Locations recently updated

The aim of this study is to compare progression free survival (PFS) in treatment-naïve Participants with KRAS p.G12C mutated metastatic colorectal ca...

Enrolling
Metastatic Colorectal Cancer
Drug: FOLFIRI Regimen
Drug: Bevacizumab-awwb
Locations recently updated

The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vin...

Enrolling
Large B-cell Lymphoma
Drug: Golcadomide
Drug: Doxorubicin

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