Dana-Farber Cancer Institute | Pediatric Hematologic Malignancy

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450 Brookline Avenue, Boston, Massachusetts, United States of America
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Leukemia (86 trials)

Breast Cancer (82 trials)

Cancer (67 trials)

Prostatic Cancer (56 trials)

Lymphoma (55 trials)

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Data sourced from clinicaltrials.gov

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73 of 808
Status: Active
Trial type: Interventional
Funder type: Industry

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll...

Metastatic Cancer
Advanced Gastrointestinal Stromal Tumors
Drug: CGT9486
Drug: Sunitinib

The purpose of this study is to collect long-term follow-up data on delayed adverse events after administration of ciltacabtagene autoleucel (cilta-c...

Multiple Myeloma
Drug: Cilta-cel

This study will evaluate the efficacy, safety, and pharmacokinetics of inavolisib in combination with palbociclib and fulvestrant compared with place...

Active, not recruiting
Breast Cancer
Drug: Placebo
Drug: Palbociclib

This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combin...

Active, not recruiting
Advanced Solid Tumors Cancer
Drug: Osimertinib
Drug: Nivolumab

This is a Phase 2 open-label, multicenter study evaluating tolerability and efficacy of navitoclax alone or when added to ruxolitinib in participants...

Active, not recruiting
Myelofibrosis (MF)
Drug: Navitoclax
Drug: Ruxolitinib

This is a Phase 1b, open-label, non-randomized, multicenter, dose-finding study evaluating venetoclax in combination with azacitidine in participants...

Active, not recruiting
Myelodysplastic Syndromes (MDS)
Drug: Venetoclax
Drug: Azacitidine

The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse....

Active, not recruiting
Cytochrome P-450
Antineoplastic Agents, Hormonal
Drug: Placebo for Abemaciclib
Drug: Abemaciclib

The purpose of this study is to determine if treatment with apalutamide plus androgen deprivation therapy (ADT) before and after radical prostatectom...

Active, not recruiting
Prostatic Neoplasms
Drug: Placebo
Drug: Apalutamide

This is a Phase Ib/II study to evaluate the safety and efficacy of autologous T cells engineered with a chimeric antigen receptor (CAR) targeting CD1...

Active, not recruiting
Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia
Biological: AUTO1

This is a study of venetoclax, daratumumab, and dexamethasone with and without bortezomib combination therapy to evaluate safety, tolerability, and e...

Active, not recruiting
Multiple Myeloma
Drug: Bortezomib
Drug: Daratumumab

This research study is studying a combination of study drugs as a possible treatment for relapsed and refractory Multiple Myeloma. The interventions...

Active, not recruiting
Multiple Myeloma
Drug: Dexamethasone
Drug: Elotuzumab

This is a phase I/II, open-label, multicenter study . During the study, subjects will be evaluated for safety, toxicity, tolerability, PK/PD, immunog...

Not yet enrolling
Solid Tumor, Adult
Drug: HB0045 Drug Product

This research study is evaluating a combination of drugs called Ofatumumab and Idelalisib as a possible treatment for Chronic Lymphocytic Leukemia (C...

Active, not recruiting
Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia
Drug: Ofatumumab
Drug: Idelalisib

The purpose of this study is to evaluate the overall minimal residual disease (MRD) negative rate of participants who receive JNJ-68284528.

Active, not recruiting
Multiple Myeloma
Drug: Lenalidomide
Drug: Daratumumab

The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2Ds) of JNJ-75276617 in combination with a conventional chemotherapy bac...

Begins enrollment in 1 month
Acute Leukemia of Ambiguous Lineage
Acute Leukemias
Drug: Dexamethasone
Drug: Pegaspargase

This research study is studying a chemotherapy drug Lenalidomide as a possible treatment for one of three histiocyte disorders: Langerhans cell histi...

Active, not recruiting
Histiocytic Sarcoma (HS)
Langerhans Cell Histiocytosis (LCH)
Drug: Lenalidomide

Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or me...

Locally Advanced Solid Tumors
Primary CNS Tumors
Drug: Oral repotrectinib (TPX-0005)

The reason for this study is to see if the study drug, selpercatinib, compared to placebo is effective and safe in delaying cancer return in particip...

Carcinoma, Non-Small-Cell Lung
Drug: Placebo
Drug: Selpercatinib

The purpose of this study is to determine the safety and tolerability of SNDX-5613 when given in combination with 2 different chemotherapy regimens i...

Active, not recruiting
Acute Lymphocytic Leukemia
Mixed Phenotype Acute Leukemia
Drug: Chemotherapy Regimen 2
Drug: Chemotherapy Regimen 1

The primary objective of this study is to determine whether treatment with daratumumab administered subcutaneously (SC) prolongs progression-free sur...

Active, not recruiting
Smoldering Multiple Myeloma
Drug: Daratumumab SC: daratumumab + rHuPH20

Trial sponsors

Dana-Farber Cancer Institute logo

Dana-Farber Cancer Institute (252 trials)

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