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Active trials

16 of 89 total trials

A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheumatic Drug (DMARD) Therapy (KEEPsAKE 1)

The purpose of this study is to compare the safety and efficacy of risankizumab versus placebo in participants with moderately to severely active pso...

Active, not recruiting
Psoriatic Arthritis
Biological: Placebo
Biological: Risankizumab

The purpose of this study is to evaluate the safety and efficacy of risankizumab in adults with moderately to severely active psoriatic arthritis (Ps...

Active, not recruiting
Psoriatic Arthritis (PsA)
Biological: Placebo
Biological: Risankizumab

The purpose of this study was to assess efficacy, including inhibition of radiographic progression, and safety with upadacitinib versus placebo and v...

Active, not recruiting
Rheumatoid Arthritis
Drug: Placebo for Upadacitinib
Drug: Upadacitinib

The purpose of this study is to evaluate the safety and reactogenicity of mRNA-1195 in healthy participants.

Active, not recruiting
Epstein-Barr Virus Infection
Biological: Placebo
Biological: mRNA-1195.1
Locations recently updated

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by...

Enrolling
Arthritis, Psoriatic
Drug: Placebo
Drug: Guselkumab

This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe...

Enrolling
Rheumatoid Arthritis
Drug: Placebo
Drug: Afimkibart
Locations recently updated

The purpose of this study is to evaluate the efficacy of icotrokinra compared to placebo in biologic-experienced participants with active psoriatic a...

Enrolling
Arthritis, Psoriatic
Drug: Placebo
Drug: Icotrokinra

A Randomized, Placebo-controlled, Multicenter, Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients with Active Pso...

Enrolling
Spondyloarthritis, Axial
Psoriatic Arthritis
Drug: Placebo
Drug: Upadacitinib 15 MG [Rinvoq]

The purpose of this study is to evaluate how well CD388 works in preventing symptomatic laboratory-confirmed influenza infections, as compared to pla...

Active, not recruiting
Influenza
Combination Product: CD388 Injection
Combination Product: Placebo

The purpose of this first-in-human study is to evaluate the safety and immunogenicity of mRNA-1468.

Active, not recruiting
Herpes Zoster
Biological: Shingrix
Biological: Placebo

This study is testing the safety, tolerability, pharmacokinetics and pharmacodynamics of GB-0895.

Active, not recruiting
Asthma
COPD (Chronic Obstructive Pulmonary Disease)
Biological: GB-0895 (SC)
Drug: Placebo (SC)

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prev...

Enrolling
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo

The purpose of this study is to learn about the safety and immune effects of a pneumococcal vaccine in adults. This vaccine can possibly provide prot...

Active, not recruiting
Pneumococcal Disease
Biological: 20-valent pneumococcal conjugate vaccine (20vPnC)
Biological: Multivalent Pneumococcal Vaccine - Formulation 2

The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and ado...

Enrolling
Migraine
Drug: Placebo
Drug: Rimegepant

The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate re...

Active, not recruiting
Arthritis, Psoriatic
Drug: Placebo
Drug: Guselkumab

The purpose of this phase 3 multicenter, randomized, double-blind, placebo-controlled rollover study is to evaluate the safety and long-term immunoge...

Active, not recruiting
Chikungunya Virus Infection
Biological: Placebo booster
Biological: CHIKV VLP vaccine booster

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