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Active trials

7 of 51 total trials

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

This is a 26-week, multi-center, randomized, double-blind, placebo-controlled study with a 4-week treatment-free Safety Follow-up period to assess th...

Enrolling
Chronic Idiopathic Constipation (CIC)
Drug: Tenapanor 50 mg BID
Drug: Tenapanor 5 mg BID

The primary objective of this trial is to evaluate the efficacy of dotinurad in lowering serum uric acid (sUA) at Week 24 in participants with gout w...

Enrolling
Gout
Drug: Dotinurad
Other: Placebo

This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk o...

Enrolling
Prehypertension
Prediabetic State
Drug: Orforglipron
Drug: Placebo
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Approximately one billion cases of seasonal influenza occur annually. Of these, 3 to 5 million illnesses are severe and responsible for up to 650,000...

Enrolling
Influenza
Combination Product: MK-1406
Combination Product: Placebo

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prev...

Active, not recruiting
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo

The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared wi...

Active, not recruiting
Osteoarthritis, Knee
Drug: Pentosan Polysulfate Sodium twice weekly
Drug: Placebo

Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a...

Active, not recruiting
Lower Respiratory Tract Illness
Biological: RSVpreF
Biological: Placebo

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