Erasmus University Medical Center | Erasmus Infectious Diseases

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Erasmus MC - Gravendijkwal 230, Rotterdam, Zuid-Holland, Netherlands
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18 of 101
Status: Active
Trial type: Interventional
Funder type: Industry

A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)

A Phase 2 open label study evaluating the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AL001 in participants with a Granu...

Active, not recruiting
Frontotemporal Dementia
Drug: AL001

The primary purpose of this study is to determine the efficacy of brigatinib by confirmed objective response rate (ORR) by response evaluation criter...

Active, not recruiting
ALK-positive Advanced NSCLC
Drug: Brigatinib

This is a Phase 1/2, multicenter, randomized, placebo-controlled, double-blind study to evaluate the safety, tolerability, pharmacokinetics (PK), and...

Active, not recruiting
Frontotemporal Dementia
Drug: DNL593
Drug: Placebo

Rationale: The choice of antithrombotic regimen during TAVI and CTO PCI includes the use of unfractionated heparin. The accuracy of ACT in this setti...

Transcatheter Aortic Valve Replacement
Percutaneous Coronary Intervention
Diagnostic Test: activated partial thrombin time

This trial investigates the efficacy and safety of clazakizumab [an anti-interleukin (IL)-6 monoclonal antibody (mAb)] for the treatment of CABMR in...

Active, not recruiting
Antibody-mediated Rejection
Biological: Clazakizumab
Drug: Physiologic saline solution

Background: Intracerebral hemorrhage (ICH) accounts for 16-19% of all strokes in Western Europe and contributes profoundly to mortality and disabilit...

Minimally Invasive Surgical Procedures
Endoscopic Surgical Procedures
Device: Minimally invasive endoscopy-guided surgery

An open-label post authorization efficacy and safety study evaluating graft failure-free survival at 1-year in highly sensitized end-stage renal dise...

Kidney Transplantation in Highly Sensitized Patients
Other: Normal Transplantation Routine
Drug: Imlifidase

This is a pivotal Phase II randomised, multi-centre, open-label study to evaluate the efficacy and safety of MB-CART2019.1 compared to standard of ca...

Diffuse Large B-cell Lymphoma
Genetic: MB-CART2019.1
Drug: R-GemOx or BR plus polatuzumab vedotin

The FAST III is a randomized controlled, open-label, multicenter, international, non-inferiority, strategy trial. A total of 2228 participants will b...

Coronary Artery Disease
Device: vFFR guided revascularization
Device: FFR guided revascularization

Clinical study to evaluate the safety and efficacy of the Adagio AF Cryoablation System (iCLAS™) in the ablation treatment of symptomatic, persistent...

Persistent Atrial Fibrillation
Device: Adagio AF Cryoablation System (iCLAS™)

The IVUS CHIP trial is a post-marketing strategy study in which patients with complex coronary lesions, undergoing percutaneous coronary intervention...

Active, not recruiting
Complex Coronary Lesions
Device: IVUS
Device: Angio

To collect information about treatment for severe aortic stenosis (AS), which affects the aortic valve in the heart. Aortic stenosis is a narrowing o...

Active, not recruiting
Ventricular Outflow Obstruction
Heart Valve Diseases
Device: JenaValve Pericardial TAVR System

The purpose of this study is to evaluate the efficacy and safety of oral masitinib versus placebo in the treatment of patients suffering from smoulde...

Indolent Systemic Mastocytosis
Other: Best Supportive Care
Drug: Masitinib

The purpose of this trial is to investigate the safety and efficacy of MyopiaX - a digital treatment intended to slow the progression of myopia in ch...

Active, not recruiting
Device: MyopiaX
Device: Myopia control spectacles

Prospective, multi-center, single-arm, seamless phase-pivotal study conducted in participants diagnosed with UUI who have failed or could not tolerat...

Active, not recruiting
Urinary Urgency Incontinence
Device: Neuspera Implantable Sacral Nerve Stimulation System

DF1001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. T...

Solid Tumor, Adult
Drug: Nab paclitaxel
Drug: Nivolumab

This is a Phase 2, multicenter, randomized, parallel, 3-arm, placebo-controlled study to assess efficacy and safety of CDR132L in patients with reduc...

Active, not recruiting
Heart Failure, Left Sided
Myocardial Infarction, Acute
Drug: CDR132L
Drug: Placebo to CDR132L

To collect information about treatment for severe Aortic Regurgitation (AR), which affects the aortic valve in the heart. Aortic regurgitation is a c...

Active, not recruiting
Aortic Regurgitation
Device: JenaValve Pericardial TAVR System

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