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Evolution Research Group | Endeavor Clinical Trials

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Acetaminophen
HTX-011
Bupivacaine HCl
Ibuprofen
VX-548
Propofol
Bupivacaine Hydrochloride
HSK3486
Tirzepatide
LY3841136

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Active trials

20 of 97 total trials

53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee

53-Week Study Evaluating the Safety and Efficacy of Intra-articular (IA) Injections of TPX-100 vs Placebo in Subjects with Mild to Severe Tibio-Femor...

Enrolling
Osteoarthritis (OA) of the Knee
Drug: TPX-100 200mg, Once weekly for 4 weeks
Other: PBS

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various...

Enrolling
Overweight
Obesity
Drug: LY3549492
Drug: LY3305677

This is a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing...

Active, not recruiting
Analgesia
Drug: HTX-011
Drug: Acetaminophen

The main objective of this study is to assess the safety and tolerability of AMG 691 as single doses (healthy participants only) and multiple doses i...

Enrolling
Asthma
Drug: Placebo
Drug: AMG 691

This is a Phase 3, randomized, double blind, multicenter study to evaluate the analgesic efficacy and safety of a single intra-articular dose of F14...

Active, not recruiting
Post Operative Pain
Drug: 0.25 % Bupivacaine HCl
Drug: Methocarbamol

The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body.Participation in Part A of th...

Enrolling
Overweight
Healthy
Drug: LY4086940
Drug: Placebo

The main purpose of this study is to see how orforglipron affects the amount of body fat compared with placebo in participants with obesity or overwe...

Active, not recruiting
Overweight
Obesity
Drug: Orforglipron
Drug: Placebo

The goal of this clinical trial is to learn about the effect of the study drug (ZT-01) on low blood sugar (hypoglycemia) in adults with type 1 diabet...

Enrolling
Type 1 Diabetes Mellitus with Hypoglycemia
Drug: Placebo
Drug: ZT-01, 22 mg

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who hav...

Enrolling
Atherosclerotic Cardiovascular Disease (ASCVD)
Elevated Lp(a)
Drug: Lepodisiran Sodium
Drug: Placebo

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to evaluate the effects of LY3549492 in adults with...

Active, not recruiting
Overweight
Obesity
Drug: Placebo
Drug: LY3549492

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate the safety and efficacy of LY3841136...

Enrolling
Overweight
Obesity
Drug: Placebo
Drug: LY3841136

This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these cond...

Enrolling
Hypertension
Cardiovascular Diseases
Drug: Placebo matching Vicadrostat
Drug: Vicadrostat

This is a Phase 2 study to evaluate the safety and efficacy of 24, 36, and 48 mg GZR18 (Q2W) compared with placebo and 15 mg tirzepatide (QW). The st...

Not yet enrolling
Obesity and Overweight
Drug: GZR18
Drug: Tirzepatide

Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus.

Active, not recruiting
Type 1 Diabetes Mellitus
Drug: BMF-219

The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilater...

Enrolling
Total Knee Arthroplasty (Postoperative Pain)
Drug: ATX101
Drug: bupivacaine hydrochloride

This Phase 1b study of DISC-0974 will assess the safety, tolerability, pharmacokinetics (PK) and Pharmacodynamics (PD) of DISC-0974 in adult particip...

Active, not recruiting
Anemia of Chronic Kidney Disease
Chronic Kidney Diseases
Drug: DISC-0974
Drug: Placebo

Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants...

Active, not recruiting
Atherosclerotic Cardiovascular Disease
Drug: Placebo
Drug: Inclisiran sodium 300 mg

A study to investigate the use of combination therapy with two investigational products for the treatment of adult patients with Nonalcoholic steatoh...

Active, not recruiting
NASH
Drug: K-877-ER
Drug: Placebo

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent...

Enrolling
Atherosclerotic Cardiovascular Disease (ASCVD)
Chronic Kidney Disease (CKD)
Drug: Retatrutide
Drug: Placebo

This study is evaluating the analgesic efficacy of intravenous (IV) tramadol (AVE-901) compared to placebo in the management of postoperative pain fo...

Active, not recruiting
Pain Management
Drug: Morphine
Other: Placebo

Trial sponsors

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Vertex Pharmaceuticals logo
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