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Evolution Research Group | Endeavor Clinical Trials

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Trials

23 of 81
Status: Active
Trial type: Interventional
Funder type: Industry

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A Chronic Weight Management Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various...

Enrolling
Overweight
Obesity
Drug: LY3305677
Drug: LY3841136

This is a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing...

Active, not recruiting
Analgesia
Drug: Acetaminophen
Drug: HTX-011

This is a Phase 3, randomized, double blind, multicenter study to evaluate the analgesic efficacy and safety of a single intra-articular dose of F14...

Active, not recruiting
Post Operative Pain
Drug: Methocarbamol
Drug: Acetaminophen

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to investigate weight management efficacy and safet...

Enrolling
Overweight and Obesity
Obesity
Drug: LY3841136
Drug: Placebo
Locations recently updated

The goal of this clinical trial is to learn about the effect of the study drug (ZT-01) on low blood sugar (hypoglycemia) in adults with type 1 diabet...

Enrolling
Type 1 Diabetes Mellitus With Hypoglycemia
Drug: ZT-01, 22 mg
Drug: ZT-01, 15 mg

This is an open-label extension to Study LPCN 1144-18-002. The study is aimed at evaluating the safety and tolerability of LPCN 1144 in adult men wit...

Active, not recruiting
NASH - Nonalcoholic Steatohepatitis
Drug: LPCN 1144

The purpose of this study is to see if the study drug, tirzepatide administered once weekly, is safe and effective as a treatment for Nonalcoholic St...

Active, not recruiting
Nonalcoholic Steatohepatitis
Drug: Placebo
Drug: Tirzepatide

PRF-110 is a viscous, yellowish clear oily solution of ropivacaine intended for administration into surgical sites to provide post-operative analgesi...

Enrolling
Bunion
Drug: Ropivacaine

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who hav...

Enrolling
Atherosclerotic Cardiovascular Disease (ASCVD)
Elevated Lp(a)
Drug: Lepodisiran Sodium
Drug: Placebo

The main purpose of this study is to assess the safety and tolerability of a single dose of LY3938577 in healthy participants and participants with T...

Enrolling
Healthy
Type 2 Diabetes Mellitus
Drug: Placebo
Drug: Insulin degludec

This study is open to adults with overweight or obesity who also have fatty liver disease. The purpose of this study is to find the highest dose of B...

Enrolling
Obesity
Non-alcoholic Fatty Liver Disease
Drug: Placebo matching BI 3006337
Drug: BI 3006337

This clinical study is a randomized, double-blind, double-dummy, parallel group, multi-center, active and placebo-controlled trial evaluating the ana...

Enrolling
Pain, Postoperative
Drug: Morphine Sulfate
Other: Intravenous Placebo for NTM-001

A open label multi-center 3-period multidose, PK/PD and drug-drug interaction (DDI) study to evaluate the pharmacokinetics (PK) and pharmacodynamics...

Enrolling
Hyperuricemia
Gout
Drug: allopurinol
Drug: dontinurad

Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus.

Enrolling
Type 1 Diabetes Mellitus
Drug: BMF-219

This is an exploratory Phase I, randomized, observer-blind, active-controlled, dose-escalation trial to evaluate four dose levels (DLs) of BNT162b4 g...

Active, not recruiting
COVID-19
SARS-CoV-2 Infection
Biological: BNT162b4 30 µg
Biological: BNT162b4 15 µg

To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if n...

Enrolling
General Anesthesia
Drug: HSK3486
Drug: Propofol

This study will compare the effects of AXA1125, an orally active mixture of amino acids, compared to placebo, on improving fat and inflammation (stea...

Enrolling
Non Alcoholic Steatohepatitis (NASH)
Drug: AXA1125
Drug: Placebo

This Phase 1b study of DISC-0974 will assess the safety, tolerability, pharmacokinetics (PK) and Pharmacodynamics (PD) of DISC-0974 in adult particip...

Enrolling
Anemia of Chronic Kidney Disease
Chronic Kidney Diseases
Drug: Placebo
Drug: DISC-0974

The objective of this study is to establish that the MB-102 transdermal fluorescence-measured Glomerular Filtration Rate (GFR) using the MediBeacon®...

Enrolling
Kidney Failure
Kidney Diseases
Device: MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
Drug: MB-102

A study to investigate the use of combination therapy with two investigational products for the treatment of adult patients with Nonalcoholic steatoh...

Enrolling
NASH
Drug: Placebo
Drug: K-877-ER

Trial conditions

Postoperative Pain (14 trials)
Fatty Liver (10 trials)
Non-alcoholic Fatty Live... (9 trials)
Acute Pain (6 trials)
Diabetes Mellitus (6 trials)
Liver Diseases (5 trials)
Onychomycosis (4 trials)
Type 2 Diabetes Mellitus (4 trials)
COVID-19 (3 trials)
Diabetic Foot (3 trials)

And 30 more

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