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SEP-363856
KarXT
Rapastinel
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Azetukalner
Brenipatide
Acetaminophen
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Active trials

22 of 125 total trials

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

This is a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing...

Active, not recruiting
Analgesia
Drug: HTX-011
Drug: Acetaminophen

X-CEED is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of azetukalner in adult part...

Enrolling
Bipolar II Disorder
Bipolar I Disorder
Drug: Placebo
Drug: Azetukalner

X-NOVA2 is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of...

Enrolling
Major Depressive Disorder
Drug: Placebo
Drug: Azetukalner
Locations recently updated

The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with Alcohol Use Disorder (AUD) and...

Enrolling
Alcohol Use Disorder
Drug: Placebo
Drug: LY3537031
Locations recently updated

The purpose of this study is to see if brenipatide when compared to a placebo works and is safe for participants with moderate-to-severe Alcohol Use...

Enrolling
Alcohol Use Disorder
Drug: LY3537031
Drug: Placebo
Status recently updated

The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when u...

Not yet enrolling
Enrolling
Opioid Use Disorder
Drug: Brenipatide
Drug: Buprenorphine

This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to plac...

Active, not recruiting
Sickle Cell Disease
Drug: Placebo Tablets
Drug: Etavopivat Tablets High dose

Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, percepti...

Enrolling
Schizophrenia
Drug: Placebo
Drug: Emraclidine

Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and se...

Enrolling
Major Depressive Disorder
Drug: Icalcaprant
Drug: Placebo for Icalcaprant

This is a phase 3, open-label extension study to assess the long-term safety of KarXT for the treatment of mania or mania with mixed features in Bipo...

Enrolling
Bipolar Disorder Type I With Mania
Drug: Valproate
Drug: Lamotrigine

This is a Phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, Pharmacokinetic (PK) and Pharmacodynamic (PD)...

Enrolling
Cognitive Impairment Associated With Schizophrenia (CIAS)
Other: Placebo
Drug: KYN-5356 low dose

The objective of this proof-of-concept study to evaluate mazdutide in participants with alcohol use disorder (AUD).For any individual participant, th...

Enrolling
Alcohol Use Disorder
Drug: Mazdutide
Drug: Placebo

The purpose of this study is to evaluate the efficacy and safety of KarXT for the treatment of manic episodes in Bipolar-I Disorder

Enrolling
Bipolar-I Disorder With Mania or Mania With Mixed Features
Drug: KarXT
Other: Placebo

This study is designed to find out how well the COVID-19 vaccine protects people 50 to 64, who don't have any serious health problems, compared to a...

Enrolling
COVID-19
SARS-COV-2 Infection
Biological: Placebo
Biological: BNT162b2 Vaccine

To evaluate long-term safety exposure

Active, not recruiting
Attention Deficit/Hyperactivity Disorder
Drug: Centanafadine Hydrochloride

Evaluate the efficacy and safety of Ulotaront (SEP-363856) in acutely psychotic subjects with schizophrenia

Enrolling
Schizophrenia
Drug: SEP-363856
Other: Placebo

This is a Phase 3, multicenter, 52-week, outpatient, open-label extension (OLE) study to evaluate the long-term safety and tolerability of adjunctive...

Enrolling
Schizophrenia
Drug: Xanomeline and Trospium Chloride Capsules

X-CEED-OLE is a Phase 3, multicenter, open-label study to evaluate the long-term safety, tolerability, and efficacy of azetukalner in adult participa...

Invitation-only
Bipolar II Disorder
Bipolar I Disorder
Drug: Azetukalner

X-NOVA-OLE is a multicenter, open-label study to evaluate the long-term safety, tolerability, and efficacy of azetukalner as a monotherapy in adult p...

Invitation-only
Major Depressive Disorder
Drug: Azetukalner

Open label extension, long-term multicenter study of safety and efficacy of SPN-812 in pediatric ADHD patients

Active, not recruiting
Attention-Deficit/Hyperactivity Disorder
Drug: SPN-812

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