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Emtricitabine
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Truvada
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imiquimod
fluorouracil
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Lenacapavir
MK-8527-007
MK-8527

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Active trials

5 of 35 total trials

A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes

The purpose of this study is to generate safety and immunogenicity data and establish a proof-of-concept of clinical benefit of the mRNA-1608 vaccine...

Active, not recruiting
Genital Herpes
Biological: mRNA-1608
Biological: BEXSERO

This double-blind, placebo-controlled study is designed to assess the safety, tolerability, and pharmacokinetics of oral MK-8527 taken once monthly (...

Active, not recruiting
HIV
HIV Pre-exposure Prophylaxis
Drug: MK-8527
Drug: Placebo to MK-8527

This is a single-arm, observational study of HIV-negative MSM with substance use disorder. Those who meet pre-screening criteria will attend a Screen...

Enrolling
Substance Use
Adherence, Treatment
Drug: Descovy or Truvada
Device: Beiwe

The goal of this clinical study is to test how well the study drug, lenacapavir (LEN), works in preventing the risk of HIV.

Active, not recruiting
Pre-Exposure Prophylaxis of HIV Infection
Drug: PTM F/TDF
Drug: Placebo SC LEN

The randomized phase of the trial compared topical or ablative treatment with active monitoring in preventing anal cancer in patients with human immu...

Active, not recruiting
Anal Cancer
High-grade Squamous Intraepithelial Lesion
Device: laser therapy
Other: clinical observation

Trial sponsors

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Janssen (J&J Innovative Medicine) logo
Mass General Brigham logo
University of North Carolina (UNC) logo
Beth Israel Lahey Health logo
Boston Children's Hospital logo
Emory University logo

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