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Active trials

5 of 36 total trials

A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes

The purpose of this study is to generate safety and immunogenicity data and establish a proof-of-concept of clinical benefit of the mRNA-1608 vaccine...

Active, not recruiting
Genital Herpes
Biological: BEXSERO
Biological: mRNA-1608

This double-blind, placebo-controlled study is designed to assess the safety, tolerability, and pharmacokinetics of oral MK-8527 taken once monthly (...

Active, not recruiting
HIV
HIV Pre-exposure Prophylaxis
Drug: MK-8527
Drug: Placebo to MK-8527

This is a single-arm, observational study of HIV-negative MSM with substance use disorder. Those who meet pre-screening criteria will attend a Screen...

Enrolling
Substance Use
Adherence, Treatment
Drug: Descovy or Truvada
Device: Beiwe

The goal of this clinical study is to look at how lenacapavir (LEN) passes through the body and to assess the safety of LEN and emtricitabine/tenofov...

Enrolling
Pre-Exposure Prophylaxis of HIV Infection
Drug: Lenacapavir Tablet
Drug: Lenacapavir Injection

The goal of this clinical study is to test how well the study drug, lenacapavir (LEN), works in preventing the risk of HIV.

Active, not recruiting
Pre-Exposure Prophylaxis of HIV Infection
Drug: PTM F/TDF
Drug: Placebo SC LEN

Trial sponsors

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Mass General Brigham logo
Brown University logo
Gilead Sciences logo
Janssen (J&J Innovative Medicine) logo
Mass General Brigham logo
University of North Carolina (UNC) logo
Ann & Robert H Lurie Children's Hospital of Chicago logo
Beth Israel Lahey Health logo

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