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Frontier Clinical Research, LLC | Smithfield , PA

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Top treatments

Orforglipron
Linaclotide
Relamorelin
Atogepant
LY3502970
Tenapanor
Tolperisone
Baloxavir Marboxil
sodium
LY573144

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Active trials

19 of 54 total trials
New

A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine

This is a long-term safety study to evaluate the safety and tolerability of intermittent use of elismetrep in the acute treatment of migraine attacks.

Begins enrollment this month
Acute Migraine
Drug: Placebo
Drug: Elismetrep

The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants w...

Active, not recruiting
Overweight
Obesity
Drug: Placebo
Drug: Orforglipron

The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.

Active, not recruiting
Crohn's Disease
Biological: JNJ-78934804
Biological: Golimumab

The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.

Active, not recruiting
Crohn Disease
Drug: Guselkumab Dose 3
Drug: Placebo

CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c...

Active, not recruiting
Primary Prevention of Atherosclerotic Cardiovascular Disease
Drug: Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
Drug: Placebo in 1.5ml

This study looks at how well a medicine called orforglipron works compared to another medicine called dulaglutide in pediatric participants aged 10 t...

Begins enrollment in 2 months
Diabetes Mellitus, Type 2
Drug: Orforglipron
Drug: Dulaglutide

The main purpose of this study is to see how orforglipron, compared with placebo, helps reduce body weight in participants with obesity or with overw...

Active, not recruiting
Overweight
Obesity
Drug: Orforglipron
Drug: Placebo

The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with...

Active, not recruiting
Overweight
Obesity
Drug: Orforglipron
Drug: Placebo

The goal of the study is to assess how tirzepatide impacts bodyweight and cardiovascular risk factors when used in conjunction with healthy nutrition...

Enrolling
Weight Gain
Obesity
Drug: Tirzepatide
Drug: Placebo

This is a double-blind, randomized, multicenter, outpatient evaluation of the efficacy, safety, and tolerability of elismetrep, as compared with plac...

Begins enrollment this month
Migraine
Drug: Placebo
Drug: Elismetrep

The purpose of this study is to learn about the safety effects of the Lyme disease vaccine (called VLA15), and its ability to protect people from Lym...

Enrolling
Lyme Disease
Biological: VLA15
Biological: Placebo

This study consists of two parts: Part A Surveillance and Part B Transmission.The main purpose of Part A is to evaluate the prevalence of pre-dose an...

Enrolling
Influenza
Drug: Baloxavir Marboxil

This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with Atherosclerotic Cardiovascular Disease (ASCVD)...

Active, not recruiting
Atherosclerotic Cardiovascular Disease
Drug: Obicetrapib
Drug: Placebo

This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these cond...

Enrolling
Hypertension
Cardiovascular Diseases
Drug: Placebo matching Vicadrostat
Drug: Vicadrostat

Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea...

Invitation-only
Migraine
Drug: Ubrogepant

Open-label long-term safety study of tenapanor in pediatric patients with IBS-C.

Invitation-only
Irritable Bowel Syndrome With Constipation (IBS-C)
Drug: Tenapanor

Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants...

Active, not recruiting
Atherosclerotic Cardiovascular Disease
Drug: Placebo
Drug: Inclisiran sodium 300 mg

Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea...

Enrolling
Migraine
Drug: Placebo-Matching Ubrogepant
Drug: Ubrogepant

This is a randomized, double-blind, placebo-controlled study to assess the efficacy, safety and tolerability of tenapanor (25 mg and 50 mg) in pediat...

Active, not recruiting
Irritable Bowel Syndrome With Constipation (IBS-C)
Drug: Tenapanor 50 MG
Drug: Placebo

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